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Mouse cluster of differentiation 6(CD6) ELISA Kit

Mouse cluster of differentiation 6(CD6) ELISA Kit

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Protocol

Code	CSB-EL004949MO
Size	96T,5×96T,10×96T
Price	Request a Quote
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Product Details
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Target Background

Product Details

Target Name

cluster of differentiation 6(CD6)

Alternative Names

Cd6T-cell differentiation antigen CD6 ELISA Kit; CD antigen CD6 ELISA Kit

Abbreviation

CD6

Uniprot No.

Q61003

Species

Mus musculus (Mouse)

Detection Range

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Sensitivity

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Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Immunology

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Description

The ELISA Kit is designed for quantitatively measuring mouse CD6 levels in samples, including serum, plasma, or tissue homogenates. It uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of CD6 in samples. The color intensity is measured at 450 nm via a microplate reader.

CD6 is a T-cell costimulatory receptor implicated in the pathogenesis of multiple autoimmune and inflammatory diseases. CD6 is mainly expressed on CD4 T cells and promotes immune synapse formation, T-cell activation, and T-cell migration through interaction with its ligand ALCAM/CD166. The CD6-ALCAM pathway modulates T cell activation, differentiation, and trafficking and thus plays an integral role in inflammation and autoimmunity. CD6 has been involved in numerous inflammatory and autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, graft versus host disease, Sjögren’s syndrome, and inflammatory bowel disease.

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Target Background

Function
(From Uniprot)

Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.

Gene References into Functions

Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases. PMID: 28760953
These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions. PMID: 28209777
these data indicate that CD6 modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells PMID: 27377588
results reveal an unexpected role of CD6 in the pathogenesis of intestinal IR-induced injury by regulating the self-renewal of B1a cells. PMID: 27909060
this analysis identified 65 proteins not associated before with the Zap70-Lat-SLP-76 network and thus should provide cues for future functional experiments. PMID: 24584089

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed predominantly in thymus, lymph node and spleen.

Database Links

KEGG: mmu:12511

STRING: 10090.ENSMUSP00000079172

UniGene: Mm.290897

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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