Mouse soluble Triggering Receptor Expresses on Myeloid Cells-1,sTREM-1 ELISA Kit

1. Results suggest that aggravation of VILI by TREM-1 in mice may be associated with TLR4-MyD88-NF-kappaB-dependent signaling. PMID: 29869715
2. Study using a mouse model of oxygen-induced retinopathy found that TREM-1 inhibition substantially downregulated retinal protein levels of TREM-1 and M-CSF suggesting that TREM-1-dependent suppression of pathological angiogenesis involves M-CSF. PMID: 29730341
3. TREM-1 is a predictive biomarker of in-stent restenosis and an important mediator of cellular inflammation, migration, and proliferation in vascular smooth muscle cells PMID: 29080545
4. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. PMID: 27762264
5. TREM-1 aggravates inflammation in acute lung injury by activating NLRP3 inflammasome, and blocking TREM-1 may be a potential therapeutic approach for acute lung injury PMID: 28004759
6. TREM-1 interventions by means of LP17, LR12 and TREM-1 fusion protein did not ameliorate IR-induced injury. In the human renal transplant cohort, donor and recipient TREM1 gene variant p.Thr25Ser was not associated with DGF, nor with biopsy-proven rejection or death-censored graft failure. We conclude that TREM-1 does not play a major role during experimental renal IR and after kidney transplantation PMID: 27928159
7. TREM-1 plays an important role in mediating platelet activation. PMID: 28837205
8. Experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE associated with increased TREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. PMID: 27328755
9. no significant effect on the severity of psoriasis PMID: 26782119
10. low expression level of TREM-1 might be a characteristic for tumor-associated macrophages in lung cancer PMID: 27244892
11. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. PMID: 28089248
12. these data suggested that TREM-1 signaling pathway may be a therapeutic target to prevent the effects of the inflammatory dendritic cells in systemic lupus erythematosus and miRNA-150 serves as the important regulator PMID: 27940256
13. The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion PMID: 27568523
14. This study is the first to show the regulatory role of TREM-1 in RLRs and TLRs expression. PMID: 27237091
15. TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis PMID: 27083877
16. in macrophages, oxidized low-density lipoprotein enhanced expression of TREM-1, which amplifies the innate immune response of Toll-like receptor pathway; activation of TREM-1 contributes to atherogenesis process by enhancing proinflammatory cytokine production and foam cell formation. PMID: 26277357
17. High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice PMID: 26250893
18. a novel positive feedback cycle mediated by TREM-1 and GM-CSF was revealed to enhance macrophage polarization under unilateral ureteral obstruction. PMID: 24918157
19. TREM-1-mediated innate immune response played an essential role in the activation of neutrophils and Streptococcus suis clearance. PMID: 26056380
20. Data indicate that triggering receptor expressed on myeloid cells-1(TREM-1) inhibition improves heart function after myocardial infarction (MI). PMID: 25840803
21. TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice PMID: 24959004
22. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PMID: 24453980
23. Data indicate that triggering receptor expressed on myeloid cells 1 (TREM-1) induces anti-apoptotic protein Bcl-2 and prolongs macrophage survival. PMID: 24711453
24. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. PMID: 24752755
25. expression of membrane and soluble form is regulated by TLR9 activation with CpG-ODN PMID: 23475790
26. Data indicate a positive correlation between serum levels of soluble TREM-1 (sTREM-1) and disease severity in infected patients as well as in experimentally infected mice. PMID: 23571837
27. TREM-1-mediated bacterial clearance in the small intestine. PMID: 24396044
28. TREM-1 plays critical roles in colon inflammation and tumor. PMID: 23810411
29. TREM-1 influences chronic heart rejection by regulating the infiltration and differentiation of CD4(+) lymphocytes. PMID: 23463907
30. These data define a new function for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies inflammation through targeted neutrophil migration into the lung. PMID: 23241959
31. Findings offer causal evidence that TREM-1 is a pivotal determinant of Kupffer cell activation in liver carcinogenesis, deepening mechanistic insights into how chronic inflammation underpins the development and progression of liver cancer. PMID: 22719066
32. TREM-1 was not expressed on lymphocytes but emerged on the cell surface of neutrophils and peritoneal macrophages. PMID: 22055202
33. TREM-1 modulates the immune response directed against A. fumigatus during experimental fungal asthma. PMID: 21592044
34. The present study has demonstrated for the first time the detailed mechanism for the basal and LPS-induced expression of TREM-1, an amplifying molecule in inflammation. PMID: 21683719
35. this study provides the fi rst evidence that TREM-1 functions as an in fl ammatory ampli fi er in P. aeruginosa keratitis by modulating TLR signaling and Th1/Th2 responses. PMID: 21555403
36. In this study, the authors delineate the role of the innate immunoreceptor TREM-1 in the parasite Schistosoma mansoni infection model from early to late (chronic) phases of infection. PMID: 21332515
37. Calcitonin gene-related peptide can regulate the LPS-induced macrophages synthesis and secretion of TREM-1. PMID: 20197606
38. The expression of TREM-1 in response to lipopolysaccharides and bacteria Pseudomonas aeruginosa is inhibited by PGD(2) and cyclopentanone prostaglandins PGJ(2) and 15-dPGJ(2). PMID: 20797396
39. crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution PMID: 15561137
40. Regulation of TREM-1 and the soluble form of TREM-1 expression by prostaglandin E2 may modulate the inflammatory response to microbial pathogens PMID: 17202378
41. septic shock induced could be attenuated by administering a Trem1-Fc fusion protein PMID: 19120482
42. TREM-1 ligation contributes to the pathology of autoimmune arthritis. PMID: 19479878
43. TREM-1 enhances responsiveness of alveolar macrophages to S. pneumoniae in vitro, and augments the early pulmonary inflammatory response PMID: 19596984

Show More

Hide All

KEGG: mmu:58217

STRING: 10090.ENSMUSP00000038636

UniGene: Mm.248352