TREM1

Myeloid cell expression trigger receptor 1 (TREM1), as an immunoglobulin superfamily activating receptor, plays an important role in the occurrence of validation responses and cascade amplification, and can affect various related cytokines in the tumor microenvironment (such as The levels of IL8, MCP1, TNFα) participate in pathological processes such as tumorigenesis, infiltration and metastasis through mechanisms such as damage, inhibition and repair, and affect the prognosis of patients. Current studies on the localization of TREM1 in the tumor microenvironment have found that TREM1 is mainly localized and expressed on the surface of stromal macrophages in ovarian cancer and non-small cell lung cancer. Compared with malignant tumors, its expression in benign tumor tissues is less.