Mouse syndecan 4 (SDC4) ELISA kit

1. SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells. PMID: 27279133
2. Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. PMID: 27751945
3. Syndecan-4 is essential for the compensated hypertrophy and the maintenance of cardiac function during the process of heart failure following pressure overload. PMID: 28395201
4. This study demonstrates that the shedding of synd4 from Endothelial progenitor cells (EPCs) plays a key role in advanced glycation end products-mediated dysfunction of EPC migration and homing. PMID: 27662820
5. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype. PMID: 26891081
6. SDC4 thus controls flow-induced lymphatic endothelial cell polarization via regulation of VANGL2 expression. PMID: 27789626
7. loss of N-sulfation leads to the disruption of the pattern of distribution of Sdc-4 within the glomeruli of Ndst1-/- mutants PMID: 26936875
8. Sdc4 has been identified as a mycobacterial attachment receptor on alveolar epithelial cells. PMID: 27279134
9. Synd4 shedding from vascular endothelial cells played an important role in the diabetes-related impairment of angiogenesis. PMID: 27018253
10. the present study demonstrated that synd4 was involved in the chemotactic migration of ECs in vitro and in vivo. PMID: 27541034
11. Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice. PMID: 26449522
12. SDC4 plays an important role in asthma induction. Disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting dendritic cells. PMID: 26165408
13. Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and calcineurin/nuclear factor of activated T-cells signalling leading to collagen PMID: 25587045
14. Locally generated Sdc4 may play a role in regulating TRPC6 channels, and may contribute to glomerular pathology. PMID: 26193076
15. Sdc4 contributes to the development of collagen induced arthritis by promoting germinal center formation and autoantibody production through its regulation of SDF-1-mediated B cell migration. PMID: 25989265
16. binding interaction between syndesmos and syn4(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance PMID: 26100207
17. the crucial role of SDC-4 for neuron density, neurite length, and branches. PMID: 25757361
18. SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression. PMID: 25174688
19. Data show that endothelial cells (ECs) from the thoracic aortas of syndecan 4 (S4-/-) mice were poorly aligned in the direction of the flow. PMID: 25404299
20. Sdc4 is required for cell surface targeting of transglutaminase 2 and the development of kidney fibrosis in chronic kidney disease. PMID: 24357671
21. The results indicate that syndecan-4 may play an important role in beta-cell function and that the cell-surface HS proteoglycans may be the missing link to maintaining islet longevity after isolation. PMID: 22872317
22. Results indicate that the DC-HIL/syndecan-4 (SD-4) pathway regulates autoimmune responses by mediating the T cell suppressor function of myeloid-derived suppressor cells (MDSCs). PMID: 24516197
23. Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. PMID: 24235146
24. Sdc4 has a dynamic expression pattern during development and is detected in tissues, including the neural tube during and following closure, the hindgut and the cochlea. Co-expression with Vangl2 is consistent with a possible role for Sdc4 in Wnt/PCP signaling during morphogenesis. PMID: 23760952
25. PGE2-induced activation of angiogenesis is mediated via syndecan-4-dependent activation of PKCalpha. PMID: 23525101
26. syndecan-4 is important for the differentiation of cardiac fibroblasts into myofibroblasts in the pressure-overloaded heart. PMID: 23178899
27. A deletion or knockdown of the Syndecan 4 effector molecule PKCalpha led to a similar reduction in phosphorylation of Thr308 while overexpression of myristoylated PKCalpha rescued AktThr308 phosphorylation in endothelial cells lacking Syndecan 4. PMID: 22975683
28. Alpha-actinin interaction with syndecan-4 has a role in stabilising cell-matrix adhesion. PMID: 22940199
29. Our results demonstrate that syndecan 4 is functionally involved in endochondral ossification and that its loss impairs fracture healing, due to inhibition of compensatory mechanisms under inflammatory conditions. PMID: 23233348
30. Arf6 is responsible for alpha5beta1-integrin recycling and thereby completes the cycle of syndecan-4-regulated integrin trafficking. PMID: 22790193
31. SD-4, as the T-cell ligand of DC-HIL, is a potent inhibitor of allo-reactive T cells responsible for GVHD and a potentially useful target for treating this disease. PMID: 23113638
32. Macrophages and epithelial cells treated with LPS had increased expression of syndecan-4. PMID: 22427536
33. Reduced Syndecan-4 is associated with severe colitis in IL-10 knockout mice. PMID: 21987406
34. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
35. The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling in glomerular permeability. PMID: 22155451
36. Interception of the Sdc4 pathway enhances infarct expansion and hypertrophic remodelling during early infarct healing in ischaemic-reperfusion injury. PMID: 21632883
37. Disruption of syndecan-4 or caveolin, gene disruption of RhoG in mice was found to retard closure of dermal wounds due to a migration defect of the fibroblasts and keratinocytes of RhoG null mice. PMID: 21982645
38. inhibits T-cell activation by employing CD148 protein tyrosine phosphatase activity PMID: 21469128
39. Syn4 plays an important role in the inflammatory response and granulation tissue formation, thereby preventing cardiac rupture and dysfunction after myocardial infarct PMID: 21493899
40. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. PMID: 21330609
41. A new houttuyfonate derivative can inhibit the proliferation of NIH3T3 cell and the expression of syndecan-4 protein induced by TNF-alpha in vitro. PMID: 20518314
42. RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. PMID: 20929862
43. Loss of syndecan-4 do not organize alpha-smooth muscle actin into bundles. PMID: 20154082
44. demonstrate the ability of syndecan-4 molecules to support cell attachment and spreading without the direct extracellular binding of integrins PMID: 20080785
45. Syndecan4 has a role in regulation of microvascular homeostasis by carrying heparan sulfate PMID: 12074629
46. role of syndecan-4 in focal adhesion kinase phosphorylation PMID: 12087088
47. Syndecan-4 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury. PMID: 12112370
48. enhanced syndecan-4 expression in mouse cardiac endothelial cells results in preferential augmentation of fibroblast growth factor 2 but not VEGF-A(165)-induced NO release PMID: 12543640
49. This protein is synthesized together with syndecan 1 by mouse mammary gland epithelial cells and bears heparan sulfate chains that are apparently structurally indistinguishable. PMID: 12571251
50. augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock PMID: 12975610

Show More

Hide All

KEGG: mmu:20971

STRING: 10090.ENSMUSP00000017153

UniGene: Mm.3815