Name: Recombinant Human Persephin protein(PSPN) (Active)
Brand: CUSABIO
SKU: CSB-AP002951HU

Product Details

Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/μg as determined by LAL method.
Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TT medullary thyroid cancer cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x10⁵ IU/mg.
Target Names	PSPN
Uniprot No.	O60542
Research Area	Neuroscience?
Alternative Names	PSPN; Persephin; PSP
Species	Homo sapiens (Human)
Source	E.Coli
Expression Region	61-156aa
Complete Sequence	ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
Mol. Weight	10.3 kDa
Protein Length	Partial
Tag Info	Tag-Free
Form	Lyophilized powder
Buffer	Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	5-10 business days
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA	Please contact us to get it.

Target Background

Function (From Uniprot)	Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Gene References into Functions	Results suggested that PSPN is a possible key regulator of oral squamous cell carcinoma (OSCC) progression via PSPN-RET-mitogen-activated protein kinase activation and that PSPN overexpression may have diagnostic potential for OSCC. PMID: 24375483 Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599 Persephin/GFRalpha4 is unable to recruit RET protein into lipid rafts. PMID: 15225646 The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons. PMID: 15829225 No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients. PMID: 18970938 Show More Hide All
Subcellular Location	Secreted
Protein Families	TGF-beta family, GDNF subfamily
Database Links	HGNC: 9579 OMIM: 602921 KEGG: hsa:5623 STRING: 9606.ENSP00000245810 UniGene: Hs.248159

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Code	CSB-AP002951HU
Size	$2617Purchase it in Cusabio online store (only available for customers from the US)
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Recombinant Human Persephin protein(PSPN) (Active)

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