Recombinant Human Interleukin-22 protein(IL22) (Active)

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Code CSB-AP001891HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.3 ng/ml, corresponding to a specific activity of >3.3x106 IU/mg.
Target Names IL22
Uniprot No. Q9GZX6
Research Area Immunology
Alternative Names Cytokine Zcyto18; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; IL-10-related T-cell-derived-inducible factor; IL-22; IL-TIF; IL21; Il22; IL22_HUMAN; ILD110; ILTIF; Interleukin 10 related T cell derived inducible factor; interleukin 21; Interleukin 22; Interleukin-22; MGC79382; MGC79384; TIFa; TIFIL 23; TIFIL23; UNQ3099/PRO10096; zcyto18
Species Homo sapiens (Human)
Source E.Coli
Expression Region 34-179aa
Mol. Weight 16.9kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 5.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Cytokine that contributes to the inflammatory response in vivo.
Gene References into Functions
  1. these findings show that CD147 is a novel and key mediator of IL-22-induced psoriatic alterations in the epidermis and might be a therapeutic target in patients with psoriasis. PMID: 28272440
  2. we have shown that variants of the IL22 gene may play an important role in the pathogenesis of CM and that these variants of IL22 are associated with an aggravation of malaria. The rs2227473 risk allele for CM, the T allele, is associated with higher levels of IL-22 production, suggesting that IL-22 contributes to CM. PMID: 28139719
  3. This study highlights a mechanism through which the IL-22 pathway facilitates the human intestinal epithelium to control microbial infection. PMID: 30217896
  4. rs1179251 polymorphism may be a risk factor for cancer [meta-analysis] PMID: 29761647
  5. the expression of miR-548a-3p is upregulated in IL-22 mediated keratinocyte proliferative disorder like psoriasis. PMID: 29181737
  6. IL-22 is involved in A549 cell resistance to paclitaxel through regulating cell apoptosis via the JNK signaling pathway. PMID: 29723165
  7. we summarize the current knowledge on the roles of IL-22 in the various pancreatic pathogenesis, providing insights into the underlying cellular and signaling mechanisms--{REVIEW} PMID: 29502986
  8. IL22 is upregulated by atorvastatin, losartan and captopril and its polymorphism may have a role in hypertension and coronary artery disease PMID: 29981321
  9. Increased IL-22 urinary level was not associated with candida urinary tract infection. PMID: 29421775
  10. The level of lncRNA H19 is increased in inflamed intestinal tissues from mice and patients. The inflammatory cytokine IL22 induces expression of H19 in IECs, which is required for intestinal epithelial proliferation and mucosal healing. H19 lncRNA appears to inhibit p53 protein and microRNA 34a and let-7 to promote proliferation of IECs and epithelial regeneration. PMID: 29621481
  11. hidradenitis suppurativa keratinocytes exhibited lower amounts of IL-22 PMID: 28972431
  12. Study shows that in Chinese subjects, the plasma concentration of interleukin-22 (IL-22) is profoundly associated with susceptibility to impaired fasting glucose (IFG) and type 2 diabetes, and decreased plasma IL-22 level is a potential trigger of IFG and type 2 diabetes. PMID: 28170163
  13. effect of IL-22 on Intestinal Epithelial Cells responses may not be in inducing CXCL8 by itself, but in enhancing TNF-alpha- and IL-1-induced CXCL8 secretion to augment the contribution of IECs to local inflammatory responses. PMID: 28656529
  14. Despite the presence of all Notch pathway molecules in the kidney and a model-specific induction of Notch ligands, IL-22 was only up-regulated in acute inflammation, but rapidly down-regulated during regeneration. This implies that for targeting injury responses, e.g. via IL-22, species-specific differences, injury type and time points have to be considered. PMID: 29054964
  15. Suggest that IL-22 has various roles in tuberculosis immune responses. In particular, membrane-bound IL-22+ T cells may play important roles in the human immune response to Mycobacterium. PMID: 29050778
  16. this study shows immunoregulatory function of lacrimal glands -derived IL-22 in inhibiting IL-17-mediated ocular surface epitheliopathy in dry eye disease PMID: 28051088
  17. Serum IL-9 and IL-22 are associated with eosinophilia in cow's milk allergy, and decrease in these two cytokines with occurs with cow's milk elimination. PMID: 28934137
  18. Tracheal aspirates of patients infected by P. aeruginosa contain protease IV activity which further results in IL-22 degradation. This so far undescribed cleavage of IL-22 by a bacterial protease is likely to be an immune-evasion strategy that contributes to P. aeruginosa-triggered respiratory infections PMID: 27792459
  19. this study shows that copy number variations of the IL-22 gene are associated with ankylosing spondylitis in Chinese Han population PMID: 28716697
  20. IL-22 contributed to the inhibition of pulmonary microvascular endothelial cells apoptosis mediated by AngII through activating the JAK2/STAT3 signaling pathway. PMID: 28827891
  21. Findings provide a new perspective on the pro-inflammatory cytokine interleukin-22 in promoting aerobic glycolysis associated with tumor progression in human colon cancer cells. PMID: 28445985
  22. finding demonstrated that IL-22 could exert favorable effects on Diabetic nephropathy (DN) via simultaneously alleviating systemic metabolic syndrome and downregulating renal NLRP3/caspase-1/IL-1beta pathway, suggesting that IL-22 might have therapeutic potential for the treatment of DN. PMID: 28726774
  23. Our findings suggested that the IL-22 -429C/T gene polymorphisms might be associated with colon cancer. PMID: 28624523
  24. Authors found that SOCS3 and SOCS1 expression was reduced in vivo, in tumor lesions of BCC and SCC, as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22-secreting TILs. PMID: 28445952
  25. miR-330 inhibits IL-22-induced proliferation of HaCaT and HKC cell by targeting CTNNB1. PMID: 28501007
  26. IL-22 protects against sodium nitroprusside-induced apoptosis in rheumatoid arthritis-fibroblast-like synoviocytes by activating the STAT3 pathway and the downstream target gene, Bcl-2. PMID: 27493089
  27. IL22 plays a critical role in maintaining barrier homeostasis against intestinal pathogens and commensal bacteria, and, as a member of the IL10 superfamily, is critically involved in inflammation [Review] PMID: 29037907
  28. TARC production in HaCaT keratinocytes through the interaction between IL-22 and IL-22Ralpha facilitates T-cell migration in atopic dermatitis caused by house dust mites. PMID: 26914146
  29. IL-22 was found to be higher in PP than in PPMS (p<0.05). PMID: 27344023
  30. IL-22 is increased in patients with GCA and affects viability and gene expression of arterial cells, supporting a potential role in disease pathogenesis. PMID: 28968695
  31. suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID: 27678220
  32. IL-18 cooperates with IL-15 to promote group 3 innate lymphoid cell (ILC3) proliferation and IL-22 production; describe an IL-18-induced, NF-kappaB-mediated mechanism that regulates IL-22 in ILC3s; at steady-state, IL-18 produced by dendritic cells mediates IL-22 production by ILC3s to help maintain normal tissue integrity PMID: 28842466
  33. results reveal that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression through the JAK/STAT pathway PMID: 28939759
  34. High serum levels of IL-22 were positively rather than inversely associated with several cardiometabolic risk factors. However, these associations did not translate into an increased risk for type 2 diabetes. PMID: 28143481
  35. mucosal-associated invariant T cells in the genital mucosa have a distinct IL-17/IL-22 profile and may have an important role in the immunological homeostasis and control of microbes at this site PMID: 27049062
  36. Results show that disease lavage IL-22 concentrations are highest in patients with pneumonia and lung cancer and does not significantly correlate with systemic inflammation. PMID: 27388918
  37. increased expression of IL-22Ralpha therefore promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL-22 PMID: 28558005
  38. In conclusion, Notch siganling appears to be an important mediator of the liver inflammation by modulating hepatic IL-22-secreting NKp46(+) innate lymphoid cells. PMID: 27800305
  39. High levels of IL-22 is associated with lyme disease. PMID: 27101991
  40. IL-23 released by keratinocytes in response to endogenous TLR4 ligands causes skin DCs, which selectively express IL-23R, to up-regulate their endogenous IL-23 production and drive an IL-22 response in naive CD4(+) T cells that mediates epidermal thickening. PMID: 27551155
  41. patients with T2DM and CAD exhibit increased serum IL-22 levels. Elevated serum IL-22 is associated with the incidence of CAD and T2DM. However, further in vitro study established the protective role of IL-22 against endothelial dysfunction, an essential process involved in the early development of atherosclerosis and vascular complications in T2DM. IL-22 might exert different functions under different context. PMID: 27829708
  42. plasma levels highly elevated after major liver resection PMID: 26853442
  43. IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration. PMID: 27166675
  44. there was no association between IL-22 SNPs (rs2227485, rs2272478, rs2227491) and the development of ulcerative colitis in a Mexican population PMID: 26994530
  45. The mutual benefit gained from interactions between the host and commensal intestinal bacteria-derived factors is an expanding field of research beginning to affect clinical practice. Data presented herein propose a supportive and fine-tuning role for butyrate in IL-22 signaling that might be therapeutically exploited by local butyrate administration PMID: 27801948
  46. this paper shows that human gammadelta T cell-antigen-presenting cells stimulate CD4+ T cell responses distinct from those induced by myeloid antigen-presenting cells to promote local barrier defense via mucosal release of IL-22 and calprotectin PMID: 28330898
  47. There was a significant direct correlation between levels of IL-10 and IL-22 in patients group (p=0.0005). The clinical severity of psoriasis was significantly correlated with high levels of IL-22 (p<0.0001). PMID: 27999243
  48. The levels of IL-22 mRNA in middle ear effusion of otitis media with effusion patients was higher in those with sinusitis than without. IL-22 expression was significantly higher in mucoid and purulent middle ear fluid samples than in serous fluid samples. PMID: 27729129
  49. IL-22 plays pathological roles in the development of recurrent hepatitis C after liver transplantation. PMID: 27123854
  50. The results suggest that IL-22 production in blood might act as a pathogenic factor in HIV infection. PMID: 25556046
  51. the effects of interleukin (IL)-22 on proliferation function and inflammatory mediator production and barrier function of human umbilical vein endothelial cells PMID: 27059499
  52. this study shows that haplotype consisting of single nucleotide polymorphism alleles in IL-2 and IL-26 genes is associated with familial vitiligo and existence of halo nevi in Estonian patients PMID: 26429320
  53. chronic smokers may have higher risk for colorectal cancer and worse prognosis due to dysregulated IL-22 production PMID: 26293897
  54. phosphorylation of STAT3 and AKT was highly induced by treatment with IL-22 via IL-22R1. IL-22R1 was also consistently overexpressed in recurrent NSCLC tissues PMID: 26983629
  55. These findings suggested that IL-18RAP rs917997, IL-32 rs2015620, IL-22 rs1179251, and interactions between these polymorphisms and H. pylori infection were associated with risks of gastric lesions PMID: 26358252
  56. In our study cohort, IL-22 serum levels were significantly elevated in active scleritis patients compared to controls and decreased significantly after remission. PMID: 27009382
  57. These data suggest that imbalance of IL-22/IL-22R1 signaling regulates the pathogenesis of chronic rhinosinusitis with nasal polyps, including local eosinophilia, via alteration of MUC1 expression. PMID: 27502468
  58. IL-22(+) CD4(+) T cells may contribute to the early process of type 2 diabetes mellitus. PMID: 25425169
  59. Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10. PMID: 26153763
  60. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID: 26329427
  61. IL-22 -429 C/T gene polymorphisms is associated with ulcerative colitis (UC) risk. PMID: 25297677
  62. IL-22 Defect During Streptococcus pneumoniae Infection Triggers Exacerbation of Chronic Obstructive Pulmonary Disease PMID: 26870795
  63. These findings provide new insights into the acetylcholine receptor-mediated regulatory mechanism of SLURP-2 expression in keratinocytes. PMID: 26033490
  64. TTP-dependent regulatory pathway described herein likely contributes to the role of IL-22 in inflammation and cancer and may evolve as novel target for pharmacological IL-22 modulation. PMID: 26486958
  65. inflammatory cytokines, including IL-17 and IL-22, are expressed at higher levels by inflamed OA synovium and suggest IL-22 involvement in OA pathophysiology. PMID: 26521730
  66. IL-17A and IL-22 work synergistically to induce antimicrobials and chemokines such as IL-8, components of calprotectin (CP), lipocalin (LCN) and some beta-defensins in both human and primary mouse gastric epithelial cells (GEC) and gastroids PMID: 26867135
  67. The study demonstrated the probable involvement of gamma delta T cells in the immune response of an organism via the secretion of IL-17 and IL-22. PMID: 26400286
  68. These results indicate that IL-22 is required for the proliferation of keratinocytes. PMID: 25939532
  69. IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis. PMID: 26781085
  70. IL-22 induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce PLA2G2A PMID: 26644377
  71. IL-22/IFN-gamma producing T-cells were significantly increased in tumour tissue and that this increase was positively correlated with TNM staging of pancreatic ductal carcinoma and poorer patient survival. PMID: 26590104
  72. High-glucose cultivation reduced IL-22 production in PBMCs that significantly reduced MMP-3 expression and hampered migration of treated keratinocytes. PMID: 25939251
  73. IL-22 can play a previously unappreciated role in controlling leishmania-induced immunopathology PMID: 26285207
  74. IL-22 gene and protein expression is reduced in the decidua of women with unexplained recurrent pregnancy loss. PMID: 25925347
  75. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22/NLRC4/IL-1Ra axis. PMID: 26269955
  76. Il-22 signaling plays role in the pathogen resistance at the epithelial-intestinal microbiota interface.Il-22 modulates the immune response in the intestinal mucosa. PMID: 26497621
  77. interferon (IFN)-alpha, weakens activation of the anti-bacterial interleukin (IL)-1/IL-22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi PMID: 26152778
  78. Urinary IL-22 mRNA level is decreased in patients with SLE with proliferative nephritis PMID: 25979722
  79. IL-22 activates miR-197 expression through the binding of phosphorylated STAT3 to sequences in the putative promoter of miR-197. PMID: 25208211
  80. To the authors' knowledge, this is the first report documenting that the IL-22 -429 C/T gene polymorphism is associated with bladder cancer risk. PMID: 26598081
  81. The mRNA expression levels of IL8 and IL22 have the potential to be useful biomarkers for determining the effects of environmental pollutants, especially PCBs, on asthmatic children and those who exhibit positive IgE responses to milk or egg proteins PMID: 25987216
  82. identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo PMID: 24796415
  83. this study identified a marked activation of Human beta-defensin-2 expression in human alveolar epithelial type II cells by IL-22. PMID: 25510212
  84. IL22/IL-22R pathway induces cell survival in human glioblastoma cells PMID: 25793261
  85. Th22 cells accumulate in colorectal cancer and may be associated with the chemotactic effect of the tumor microenvironment. IL-22 is associated with CRC development, most likely via STAT3 activation. PMID: 25892871
  86. Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells. PMID: 26378072
  87. the elevated levels of IL-22 in active MM patients, in parallel with disease activity, and in positive correlation with IL-1beta, may represent the inflammatory element of the disease. PMID: 25055724
  88. Interleukin-22 has a prominent role in the pathogenesis and therapy of rheumatoid arthritis. (Review) PMID: 25483133
  89. Interleukin-22 - friend or foe. PMID: 25608673
  90. Data suggest that Th22 cells (T-lymphocytes producing/secreting IL22) may contribute to autoimmunity and pathogenesis of Hashimoto's thyroiditis in humans and a model of autoimmune thyroiditis in NOD mice. PMID: 25242258
  91. DR3 is expressed by IL-22-producing human group 3 innate lymphoid cells (ILC3s). PMID: 26046454
  92. Serum IL-22 is increased in newly diagnosed, untreated Hashimoto's thyroiditis patients, as compared to thyroid autoimmune disease-free individuals. PMID: 25079457
  93. IL-22 could be an important biomarker of inflammation in preeclampsia. PMID: 25407645
  94. Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis. PMID: 25792465
  95. increased serum levels in patients with allergic rhinitis correlate with the level of allergen-specific IgE PMID: 25514475
  96. susceptibility of gastric MALT lymphoma is influenced by genetic polymorphisms in IL-22, the product of which is involved in mucosal immunity against H. pylori and associated with tumor response to H. pylori eradication. PMID: 25303370
  97. In acute pancreatitis, high plasma levels of IL-22 are observed, regardless the severity of the disease PMID: 25240697
  98. IL-22 may contribute to the fibrogenesis of HCV-associated liver fibrosis by activating hepatic stellate cells. PMID: 25771172
  99. Suggest IL-22 plays the important role in the pathogenesis of chronic rhinosinusitis. PMID: 25337212
  100. Increased expression of IL-22 may play an important role in endometrial stromal cell invasion and finally contribute to the origin and development of adenomyosis. PMID: 25337217

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Subcellular Location Secreted
Protein Families IL-10 family
Database Links

HGNC: 14900

OMIM: 605330

KEGG: hsa:50616

STRING: 9606.ENSP00000329384

UniGene: Hs.287369

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