FUT4 Monoclonal Antibody

Code CSB-MA000264
Size US$167
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Product Details

Uniprot No. P22083
Target Names FUT4
Alternative Names 3)-fucosyltransferase antibody; Alpha-(1 antibody; Alpha-(1,3)-fucosyltransferase antibody; Alpha-3-fucosyltransferase antibody; ELAM-1 ligand fucosyltransferase antibody; ELFT antibody; FCT3A antibody; Fuc-TIV antibody; Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific antibody; Fucosyltransferase 4 antibody; Fucosyltransferase IV antibody; FucT-IV antibody; Fut4 antibody; FUT4_HUMAN antibody; FUTIV antibody; Galactoside 3-L-fucosyltransferase antibody; Lewis X antibody; LeX antibody; SSEA-1 antibody; Stage-Specific Embryonic Antigen 1 antibody
Raised in Mouse
Species Reactivity Human
Immunogen Synthetic Peptide
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Gene References into Functions
  1. LOX-1(+) CD15(+) polymorphonuclear myeloid-derived suppressor cells were elevated in hepatocellular carcinoma patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress. PMID: 29211299
  2. Low FUT4 expression is associated with Head and Neck Squamous Cell Carcinoma. PMID: 28681122
  3. Data suggest that FUT4 is aberrantly up-regulated in chondrocytes of osteoarthritis articular cartilage; FUT4 is a direct target of MIR26A and MIR26B via NFkappaB signal transduction. (FUT4 = fucosyltransferase-4; MIR26A = microRNA 26a; MIR26B = microRNA 26b) PMID: 29208566
  4. Suggest that lactoferrin and CD15 may serve as specific markers to corroborate a definitive diagnosis in septic cardiomyopathy. PMID: 29809052
  5. Authors demonstrated that miR-200c targeted and inhibited FUT4 expression, leading to the dysfunction of uterine receptivity. Results also revealed that miR-200c decreased alpha1.3-fucosylation on glycoprotein CD44, which further inactivated Wnt/beta-catenin signaling pathway. PMID: 28914881
  6. The identified colorectal cancer-restricted miR-26a and miR-26b might be implicated in cancer progression via their target gene FUT4. PMID: 28640257
  7. CD15 is a significant prognostic factor in clear cell renal cell carcinoma. PMID: 29036563
  8. FUT4/LeY was critical to the TAMs-mediated EMT; this process might be associated with the up-regulation of Ezrin phosphorylation by FUT4/LeY-mediated fucosylation PMID: 28423676
  9. study enhances the understanding of cancer cell-brain endothelial adhesion and confirms that CD15 plays a crucial role in adhesion PMID: 26472821
  10. CA19-9-Low&Lewis (+) pancreatic cancer is a unique subtype with special biological properties. PMID: 27840089
  11. We observed an upregulation of the transcription factors OCT4 and SOX2 in leukemic cells as compared to normal cells. Conversely, SSEA1 protein was downregulated in leukemic cells. The expression of OCT4, SOX2, and SSEA3 was higher in CD34(+)CD38(-) than in CD34(+)CD38(+) subsets in leukemic cells. PMID: 28718379
  12. is a sensitive and specific marker for intraepithelial and invasive neoplasias of the bile duct PMID: 27442966
  13. The miR-493-5p/FUT4 pathway has therapeutic potential in breast cancer. PMID: 27375041
  14. expression of SSEA-1 immunoreactivity in thyroid neoplasms was associated with more aggressive thyroid carcinomas PMID: 27550342
  15. Data show that after FUT4 down-regulated with siRNA (shFUT4), epithelial-mesenchymal transition (EMT) was obviously inhibited. PMID: 26636541
  16. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions PMID: 26427350
  17. the acquisition of a sialyl moiety by the CD15 antigen may precede the widespread dissemination in Hodgkin lymphoma. PMID: 26418972
  18. MMP-2 and sLe(x) were negative prognostic markers for survival in these head and neck squamous cell carcinoma patients. PMID: 24171785
  19. A subset of choroidal and ciliary body melanomas overexpress the CD15 antigen. PMID: 26290260
  20. Cancer-related CD15/FUT4 overexpression participates in cetuximab or bevacizumab mechanisms of resistance in metastatic colorectal cancer patients. PMID: 26427914
  21. This provides an automated procedure, which shortens the mentally tiring and time-consuming process of microscopic cell counting and thus makes a contribution towards the standardization of tools for diagnosing PJI. PMID: 25869074
  22. Our results indicate that FUT4 and miR-224-3p are crucial regulators of cancer response to chemotherapy, and may serve as therapeutic targets to reverse chemotherapy resistance in breast cancer. PMID: 26701615
  23. Physiologically immature placentas and pathologically immature term placentas were characterized by marked endothelial CD15-immunostaining. Significant loss of CD15-positive endothelium was associated with physiological and accelerated villous maturity. PMID: 25043745
  24. Data suggest that changes in DNA methylation in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4), and (3) matrix metalloproteinase (MMP2 and MMP9) activity. PMID: 25697377
  25. A significant high expression of FUT4 in breast cancer tissues and serum was found compared to controls. PMID: 25776515
  26. This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/beta-catenin signaling pathway PMID: 25896022
  27. level of expression in the macro- and microvasculature reflects the degree of pathological placental villous immaturity PMID: 25149387
  28. The presence of nanog, Oct-4, SSEA-1, and SSEA-4 suggests that periodontal ligament mesenchymal stem cells are less differentiated than bone marrow-derived MSCs, and the frizzled-9/Wnt pathway is important in proliferation and differentiation. PMID: 20458727
  29. The lower expression of FUT4 in HaCaT cells is correlated with the methylation of CpG island in FUT4 promoter. PMID: 25608813
  30. Titration of the monomeric DC-SIGN CRD with Le(X) monitored by 2D NMR revealed significant perturbations of DC-SIGN cross-peak positions in (1)H-(15)N heteronuclear single quantum coherence (HSQC) spectra and identified residues near the binding site. PMID: 25121780
  31. The correlation of sLex overexpression in primary tumors and metastatic lymph nodes, the discrimination among the normal, adenoma, and CRC groups based on sLex expression. PMID: 24425323
  32. FUT4 is a target gene for HSF1 and Sp1 that is required for cell cycle progression in breast cancer epithelial cells.HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells. PMID: 23959823
  33. AQP9 expressing glioma cells were negative for the brain tumor stem cell marker CD15. PMID: 24086629
  34. Results suggest that FUT4-, FUT6- or FUT8-mediated MDR in human HCC is associated with the activation of the PI3K/Akt pathway and the expression of MRP1. PMID: 24232099
  35. The expression of ST3GAL4 leads to SLe(x) antigen expression in gastric cancer cells which in turn induces an increased invasive phenotype through the activation of c-Met PMID: 23799130
  36. Lewis x appeared to be a new, reliable marker that can be used to clearly distinguish invasive hydatidiform moles from choriocarcinomas. PMID: 23681114
  37. TNF increases the expression of alpha2,3-sialyltransferase gene ST3GAL4 PMID: 22691873
  38. High CD15 expression is associated with medulloblastoma. PMID: 22411914
  39. the expression of Lewis Y and FUT4 correlates with endometrial receptivity PMID: 22145955
  40. FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter. PMID: 22287018
  41. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma PMID: 21931765
  42. Resting natural killer (NK) cells that have been coincubated with NK-resistant CD15-positive tumor cells lyse Raji cells and are capable of lysing a variety of NK-resistant tumor cells of different lineages. PMID: 22084431
  43. Data indicate that among MDS cases, CD15+ and CD19+ cell TLs were positively correlated, and PBL TL was was not associated with hTERT genotype. PMID: 21635204
  44. Data show that tumours induced by transformed fibroblasts are hierarchically organized, and the cells that act as CSCs to initiate and maintain tumour growth are marked by the stage-specific embryonic antigen SSEA-1. PMID: 21857669
  45. NEU4 plays an important role in control of sialyl Lewis antigen expression and its impairment in colon cancer PMID: 21521691
  46. CD15-expressing nodular lymphocyte-predominant Hodgkin lymphoma PMID: 21457163
  47. FUT4 inhibited cell apoptosis through decreasing the expression of apoptotic proteins and increasing the expression of anti-apoptotic protein Bcl-2 PMID: 21337384
  48. The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach. PMID: 20965272
  49. In endometrial tissues, knockdown of FUT4 expression reduces expression of Lewis Y antigen but not of integrin alphavbeta3. PMID: 20605574
  50. Findings suggest the important role of the CD11b+/CD14/CD15+/CD33+ MDSCs in mediating immunosuppression in NSCLC. PMID: 19572148

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Subcellular Location Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein
Protein Families Glycosyltransferase 10 family
Database Links

HGNC: 4015

OMIM: 104230

KEGG: hsa:2526

STRING: 9606.ENSP00000351602

UniGene: Hs.390420

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