ITGAL Monoclonal Antibody,FITC Conjugated

Datasheet
Code CSB-MA120024
Product Type Monoclonal Antibody
Size US$258
Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Flow Cytometry (FC) Protocol
Immunogen
Raised in Mouse
Species Reactivity Human
Specificity
Tested Applications ELISA,IF,FC;Recommended dilution:IF:1:100-1:200
Relevance

 4A122 reacts with CD11a, a 180 kDa molecule. CD11a is the a chain of the leukocyte function associated antigen-1 (LFA-1a), and is expressed on all leukocytes including T and B cells, monocytes, and granulocytes, but is absent on non-hematopoietic tissue and human platelets. CD11/CD18 (LFA-1), a member of the integrin subfamily, is a leukocyte adhesion receptor that is essential for cell-to-cell contact, such as lymphocyte adhesion, NK and T-cell cytolysis, and T-cell proliferation. CD11/CD18 is also involved in the interaction of leucocytes with endothelium.

*CD11a antibody has been used to reduces graft failure for bone marrow grafts in immunodeficient children. This clone is cross reactive with non-human primate.
 
1. Schlossman. S et al. (1995) Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
2. Lub M et al. (1995) Immunol. Today 16:479.
3. Sanchez-Mateos P et al. (1996) Cancer Biol. 7:99.
Form Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Isotype IgG1
Clonality Monoclonal
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Clone No. 4A122
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