PGC Monoclonal Antibody

Code CSB-MA112991A0m
Size US$350Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemical of paraffin-embedded human gastric cancer tissue using CSB-MA112991A0m at dilution of 1:200

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Product Details

Full Product Name mouse anti-Homo sapiens (Human) PGC monoclonal antibody
Uniprot No. P20142
Target Names PGC
Alternative Names Gastricsin antibody; PEPC antibody; PEPC_HUMAN antibody; pepsin C antibody; Pepsinogen C antibody; pepsinogen group II antibody; PGC antibody; PGII antibody; preprogastricsin antibody; Progastricsin antibody
Raised in mouse
Species Reactivity Human
Immunogen Recombinant Human PGC
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality monoclonal
Isotype IgG1
Clone No. 1G1H3
Purification Method >95%,protein G purifed
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Hydrolyzes a variety of proteins.
Gene References into Functions
  1. Recombinant pepsin C and pepsinogen C were purified from transgenic rice culture medium, and the NH2-terminal 5-residue sequences were verified by amino acid sequencing. PMID: 29108629
  2. serum levels correlated with age, sex and the level of Helicobacter pylori infection PMID: 27865295
  3. Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. PMID: 26486507
  4. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer. PMID: 25857852
  5. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis. PMID: 26158864
  6. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17] PMID: 22066020
  7. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer. PMID: 25551587
  8. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication. PMID: 25028655
  9. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions. PMID: 24895149
  10. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer. PMID: 24586594
  11. plasma PG II level significantly correlated with H. pylori-infected gastric cancer PMID: 23326145
  12. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis. PMID: 24009139
  13. Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux. PMID: 23311720
  14. PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to atrophic gastritis and/or gastric cancer. PMID: 23455381
  15. Data suggest that serum pepsinogen I/II ratio (pepsinogen A/C ratio) is correlated with diabetic nephropathy and thus may be a biological marker for degree of urinary albumin excretion in patients with type 2 diabetes. PMID: 23047493
  16. The serum levels of PG II and G-17 were significantly higher in Changle than those in Fuan. PMID: 23117263
  17. Data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms. PMID: 23178618
  18. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured. PMID: 22066020
  19. Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies. PMID: 21303408
  20. PGC gene insertion/deletion polymorphism is negatively related to PGC protein expression in gastric mucosa, but is not related to the serum PGC level. PMID: 19624876
  21. Pepsinogen C insertion/deletion polymorphism and Helicobacter pylori infection seem to present a positive interaction in the development of gastric cancer. PMID: 19173902
  22. Pepsinogen C is expressed in a quarter of ovarian carcinomas and might identify a subset of patients with different prognosis PMID: 12128264
  23. These results suggest that there is some relation between pepsinogen C gene polymorphism and gastric cancer, and the person with homogenous allele 1 predisposes to gastric cancer more than those with other genotypes. PMID: 12508350
  24. results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach PMID: 12698190
  25. human cathelicidin antimicrobial peptide-18 in seminal plasma is processed to generate a 38-amino acid antimicrobial peptide ALL-38 by the prostate-derived protease gastricsin when incubated at a pH corresponding to the vaginal pH PMID: 12759353
  26. Pepsinogen C can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer. PMID: 15200883
  27. pepsinogen C may be expressed by uveal melanoma and suggest that this protein could be considered as a new, unfavorable prognostic factor in these tumors PMID: 15503827
  28. Higher levels of Pepsinogen II is associated with early gastric cancer PMID: 15688378
  29. pepsinogen C genetic variants have a role in gastric cancer PMID: 16937501
  30. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. PMID: 17559360
  31. pepsinogen C has a role in SP-B proteolytic processing in alveolar type 2 cells PMID: 18256027
  32. role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients PMID: 18447628
  33. pepsinogens may have a role in esophageal squamous dysplasia PMID: 18844222
  34. The pepsinogen C gene polymorphism increases an individual's susceptibility to gastric cancer and its precancerous conditions PMID: 19132389
  35. Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the stomach corpus. PMID: 19731026

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Subcellular Location Secreted
Protein Families Peptidase A1 family
Database Links

HGNC: 8890

OMIM: 169740

KEGG: hsa:5225

STRING: 9606.ENSP00000362116

UniGene: Hs.1867

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