Human Casein

Code CSB-NP008801h
Product Type Native Protein
Size US$3605Purchase it in Cusabio online store
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please order from local distributors.)
Relevance Casein contains a fairly high number of proline residues, which do not interact. There are also no disulfide bridges. As a result, it has relatively little tertiary structure. It is relatively hydrophobic, making it poorly soluble in water. It is found in milk as a suspension of particles called "casein micelles" which show only limited resemblance with surfactant-type micellae in a sense that the hydrophilic parts reside at the surface and they are spherical. However, in sharp contrast to surfactant micelles, the interior of a casein micelle is highly hydrated. The caseins in the micelles are held together by calcium ions and hydrophobic interactions. Several models account for the special conformation of casein in the micelles (Dalgleish, 1998). One of them proposes the micellar nucleus is formed by several submicelles, the periphery consisting of microvellosities of κ-casein (Walstra, 1979; Lucey, 2002). Another model suggests the nucleus is formed by casein-interlinked fibrils (Holt, 1992). Finally, the most recent model (Horne, 1998) proposes a double link among the caseins for gelling to take place. All three models consider micelles as colloidal particles formed by casein aggregates wrapped up in soluble κ-casein molecules.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Tested Applications ELISA, WB, SDS-PAGE
Form Liquid
Storage Buffer PBS, pH 7.4
Alias N/A
Biological_Activity Not test
Purity >95% (SDS-PAGE)
Sequence Full length protein
Research Area Cell Biology
Source Purified from Human milk
Protein Names Human Casein
Storage Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
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Q&A and Customer Reviews

Q&A
Q:

1. What is the scale you are capable of producing ?
2. How similar is it to natural milk proteins?
3. Does it involve genetic modification?

A:
Very nice to receive your inquiry.
1. Capacity is proportional to the roundtime which depends on customer's demand. We could produce an average of 10-100mg per 4 days.
2. What we produce is human natural protein. The similarity that you mentioned should refer to sequence similarity?
3. Natural proteins are linear epitopes, with complete conformational epitopes.
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