Human Neutrophil gelatinase-associated lipocalin protein

Code CSB-NP068341h
Product Type Native Protein
Size US$630Purchase it in Cusabio online store
(only available for customers from the US)
Relevance Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2, 5-dihydroxybenzoic acid (2, 5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Tested Applications ELISA, WB, SDS-PAGE. Latex enhanced turbidimetric immunoassay (LETIA), immunogen and other possible
Form Liquid
Storage Buffer PBS, pH 7.4
Alias N/A
Biological_Activity Not test
Purity >95% (SDS-PAGE)
Sequence Full length protein
Research Area Immunology
Source Purified from Human urine
Protein Names Human Neutrophil gelatinase-associated lipocalin protein
Storage Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
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