ABCC5 Antibody

Datasheet
Code CSB-PA001064LA01HU
Size US$299
Image
  • IHC image of CSB-PA001064LA01HU diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA001064LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of PC-3 cells with CSB-PA001064LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABCC5 Polyclonal antibody
Uniprot No. O15440
Target Names ABCC5
Alternative Names ABC 33 antibody; ABC33 antibody; ABCC 5 antibody; Abcc5 antibody; ATP binding cassette sub family C (CFTR/MRP) member 5 antibody; ATP binding cassette sub family C member 5 antibody; ATP-binding cassette sub-family C member 5 antibody; Canalicular multispecific organic anion transporter C antibody; DKFZp686C1782 antibody; EST277145 antibody; MOAT C antibody; MOAT-C antibody; MOATC antibody; MRP 5 antibody; MRP5_HUMAN antibody; Multi specific organic anion tranporter C antibody; Multi-specific organic anion transporter C antibody; Multidrug resistance associated protein 5 antibody; Multidrug resistance-associated protein 5 antibody; pABC 11 antibody; pABC11 antibody; SMRP antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Multidrug resistance-associated protein 5 protein (455-566AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene References into Functions
  1. ABCC5 polymorphisms may explain partially the interpatient variability in doxorubicin disposition. PMID: 26975227
  2. This study is the first to identify the roles of FOXM1 in drug efflux and paclitaxel resistance by regulating the gene transcription of abcc5, one of the ABC transporters. Small molecular inhibitors of FOXM1 or ABCC5 have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma (NPC)patients. PMID: 28277541
  3. These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region. PMID: 28813580
  4. Survivors of childhood acute lymphoblastic leukemia treated with doxorubicin with the ABCC5 TT-1629 genotype had an average of 8-12% reduction of ventricular ejection and shortening fractions. PMID: 26345518
  5. our work indicated that decreased SLC34A2 expression sensitized BCSCs to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling and shed new light on understanding the mechanism of chemoresistance in BCSCs. This study not only bridges the missing link between stem cell-related transcription factor (Bmi1) and ABC transporter (ABCC5) but also contributes to development of potential therapeutics against breast cancer. PMID: 26546432
  6. Deletions of ABCC5 predict good tumor response to neoadjuvant chemotherapy in breast cancer. PMID: 26799285
  7. genetic association study in population in Mexico: Data suggest SNPs in ABCC5 (3933+313T>C) are not associated with adverse reactions to methotrexate; they protect against myelosuppression in pediatric patients with ALL (acute lymphoblastic leukemia). PMID: 26353179
  8. We identified several genes (FasL, MSH2, ABCC5, CASP3, and CYP3A4)that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome PMID: 25829401
  9. ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs. PMID: 26515061
  10. The present study investigated the time course and dose dependency of the induction of three efflux proteins, P-gp, MRP1 and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels. PMID: 25564970
  11. cCMP is a substrate for MRP5 PMID: 25017019
  12. The blockade of ABC transporter MRP5 could help to improve drug effectiveness, reduce tumour growth and prevent recurrence in glioblastoma multiforme. PMID: 25028266
  13. To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation. PMID: 25964343
  14. ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations. PMID: 25117150
  15. ABCC5 functions as a mediator of breast cancer skeletal metastasis. ABCC5 expression in breast cancer cells is important for efficient osteoclast-mediated bone resorption. PMID: 23174366
  16. This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 primary angle closure glaucoma cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). PMID: 24603532
  17. Further research is needed to clarify whether MRP5 is indicative of malignant pathological features in meningiomas and whether possible therapeutic implications exist PMID: 23271324
  18. PDE5 is highly expressed and increases ( approximately 130%) during growth whereas ABCC5 exhibited low to moderate expression, with a moderate increase ( approximately 40%) during growth PMID: 22843873
  19. The present results imply that MRP5 index may hold a prognostic role in patients with glioblastoma multiforme PMID: 22278731
  20. Findings show that the gene expression of ATP-dependent efflux transporters MRP1, -3, -4, -5, and p-gp fluctuated during stem cell-derived retinal pigment epithelial cells (hESC-RPE) maturation. PMID: 22272278
  21. This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy PMID: 21449672
  22. Results support the idea that isolating survivin and MRP5+ CTCs may help in the selection of metastatic colorectal cancer patients resistant to standard 5-FU and L-OHP based chemotherapy, for which alternative regimens may be appropriate. PMID: 20597995
  23. Results identify key membrane transporters OATP2B1, MRP1, MRP4, and MRP5 as modulators of skeletal muscle statin exposure and toxicity. PMID: 19940267
  24. MDR1, MRP2, MRP3 and MRP5 levels are decreased by tetramethylpyrazine in human hepatocellular carcinoma cells PMID: 19956884
  25. Sodium influx is not directly coupled to MRP4/5-mediated cyclic nucleotide efflux, is independent of the status of transporter activity, and determines the baseline membrane potential, which in turns modulates MRP4/5-mediated cyclic nucleotide efflux. PMID: 19903828
  26. MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cGMP synthesis is strongly induced and phosphodiesterase activity is limiting PMID: 12637526
  27. MRP1 and MRP5 increase with trophoblast maturation, suggesting a particular role for these proteins in the organ functional developmen PMID: 12646196
  28. the affinity of MRP4 and MRP5 for nucleotide-based substrates is low. PMID: 12695538
  29. Localized in cardiac and cardiovascular myocytes as well as endothelial cells with increased expression in ischemic cardiomyopathy. MRP5-mediated cellular export may represent novel, disease-dependent pathway for cGMP removal from cardiac cells. PMID: 14507663
  30. MRP5 expression depends on gestational age and varies throughout the differentiation process. PMID: 15631998
  31. Upregulation of MRP5 expression is associated with pancreatic carcinoma PMID: 15688370
  32. analysis of linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus PMID: 15861033
  33. Plant flavonoids were able to reverse drug resistance in human cells transfected with ABCC5 PMID: 16156793
  34. We have isolated three novel ABCC5 splice variants and characterized their role in the regulation of ABCC5 gene expression. One ABCC5 splice variant produces a truncated ABCC5 protein isoform with thus far unknown functional properties in the retina. PMID: 17521428
  35. cGMP may be a physiological regulator of hyaluronan export at the level of the export MRP5 PMID: 17540771
  36. analysis of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5) PMID: 17803828
  37. Celecoxib upregulates MRP5 in colon cancer and results in lack of synergy with standard chemotherapy. PMID: 18690847
  38. MRP3, MRP4, and MRP5 are upregulated in 5-fluorouracil-resistant cells, and MRP5 contributes to 5-FU resistance in pancreatic carcinoma cells. PMID: 19077464

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity All isoforms are equally expressed in retina.
Database Links

HGNC: 56

OMIM: 605251

KEGG: hsa:10057

STRING: 9606.ENSP00000333926

UniGene: Hs.368563

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