ABI1 Antibody

1. our findings indicated that ABI1 contributes to the development and progression of hepatocellular carcinoma (HCC) as an oncogene and may serve as a valuable prognostic marker for HCC patients. PMID: 28339046
2. these data indicate that HCV exploits host Abi1 protein via NS5A to modulate MEK/ERK signaling pathway for its own propagation. PMID: 27551040
3. Suggest that Abi1 acts as a tumor-promoting gene in epithelial ovarian cancer progression, which may lead to unfavorable prognosis. PMID: 26193797
4. These results indicate that the alpha4-Abi-1 signaling pathway may mediate acquisition of the drug-resistant phenotype of leukemic cells. PMID: 24699303
5. Our data indicate that phosphorylated Abi1 contributes to the invasive properties of colorectal cancer. PMID: 24913355
6. Abi1 is expressed at the invasive front of colorectal carcinomas and localizes to the leading edge of lamellipodia in cultured colorectal carcinoma cells. PMID: 24196611
7. Data indicate that Abi1 is activated by the c-Abl-Crk-associated substrate (CAS) pathway, and Abi1 reciprocally controls the activation of its upstream regulator c-Abl. PMID: 23740246
8. a possible role for Abi1 as a marker for early KRAS mutation in hyperplastic polyps PMID: 22808230
9. Breast tumors expressing high levels of Abi1 are significantly associated with early recurrence and worse survival on multivariate analysis. PMID: 21046228
10. Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis. PMID: 22430194
11. The phosphorylation and dephosphorylation cycle of VASP by the Abi-1-bridged mechanism regulates association of VASP with focal adhesions, which may regulate adhesion of Bcr-Abl-transformed leukaemic cells. PMID: 22014333
12. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis PMID: 21900237
13. Expression of Abi1 is up-regulated in hepatocellular carcinoma tissues compared with corresponding para carcinomatous liver tissue, and is significantly correlated with tumor number, capsular formation, venous invasion, grade and prognosis. PMID: 20137729
14. Data show that disruption of phosphorylation sits Y398 and Y213 significantly weakens the binding of Abi-1 to c-Abl. PMID: 21320496
15. Study implicates that the integrity of SOS1/EPS8/ABI1 tri-complex is a determinant of ovarian cancer metastasis. PMID: 21118970
16. Downregulation of ABI1 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis. PMID: 19554484
17. Macropinocytosis is regulated by interactions between Abi1 pY213 and the C-terminal SH2 domain of p85-thereby linking Abl kinase signaling to p85-dependent regulation of macropinocytosis. PMID: 20598684
18. Abi1 isoforms differentially regulate macropinocytosis as a consequence of their different relative affinities for activated Rac1 in Wave 2 complex. PMID: 20479892
19. The ABI1 gene is down-regulated in gastric cancer cells. ABI1 overexpression effectively inhibits cell proliferation. PMID: 20193272
20. Combination of experimental and computational interactome research was used for the analysis of protein-protein interactions between Abi-1 and VASP in human platelets. PMID: 20110575
21. t(10;11)(p11.2;q23) involving MLL and this gene is associated with congenital acute monocytic leukemia PMID: 12547160
22. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins PMID: 12672821
23. Abi1 interacts directly with the WHD domain of WAVE2, increases WAVE2 actin polymerization activity and mediates the assembly of a WAVE2-Abi1-Nap1-PIR121 complex. PMID: 15048123
24. Abi enhances Abl-mediated downregulation and phosphorylation of Cdc2 kinase PMID: 15591787
25. Abi-1-mediated coupling of Abl to WAVE2 promotes Abl-evoked WAVE2 tyrosine phosphorylation required to link WAVE2 with activated Rac and with actin polymerization and remodeling at the cell periphery. PMID: 15657136
26. We demonstrate a cell-type-dependent requirement for various WASP-related proteins in Listeria entry and InlB-induced membrane ruffling; Abi1, a key component of WAVE complexes, is recruited at the entry site PMID: 15769844
27. Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions PMID: 15893754
28. Overexpression of e3B1 in NIH3T3/EGFR cells sensitized EGF-induced activation of Rac1, whereas it had no impact on EGF-induced activation of p21Ras. PMID: 16182283
29. results suggest that the Eps8/Abi1 complex is capable of regulating the localization and/or activity of actin nucleators PMID: 16225669
30. c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo; Abi-1 forms the crucial link between these two factors PMID: 16899465
31. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl. PMID: 17101133
32. Data show that Chlamydia trachomatis activates Rac and promotes its interaction with WAVE2 and Abi-1 to activate the Arp2/3 complex resulting in the induction of actin cytoskeletal rearrangements that are required for invasion. PMID: 17501982
33. by activating the Abi1 pathway, Bcr-Abl induces a translocation of MT1-MMP to a membrane-associated structural complex enriched with F-actin and adhesion molecules. PMID: 17943163
34. ABI-1 plays an important role in the spread of breast cancer and this role may be mediated via the phosphatidylinositol 3-kinase pathway. PMID: 17951403
35. c-Abl kinase inhibition mediated by a phosphotyrosine located in trans in the c-Abl substrate, Abi1. PMID: 18328268
36. These findings uncover a novel link between cadherin-mediated adhesion and the regulation of actin dynamics through the requirement for an Abi/Dia complex for the formation and stability of cell-cell junctions. PMID: 19158278
37. Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells PMID: 19843640
38. Human SSH3BP1 is a marker of macropinocytic vesicles and potential regulator of macropinocytosis in mammalian cells. SSH3BP1 may play a role in fusion of macropinocytic vesicles. PMID: 11034908

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HGNC: 11320

OMIM: 603050

KEGG: hsa:10006

STRING: 9606.ENSP00000365312

UniGene: Hs.508148