ADAM19 Antibody

Code CSB-PA880929ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA880929ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880929ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADAM19 Polyclonal antibody
Uniprot No. Q9H013
Target Names ADAM19
Alternative Names ADAM19 antibody; MLTNB antibody; FKSG34Disintegrin and metalloproteinase domain-containing protein 19 antibody; ADAM 19 antibody; EC 3.4.24.- antibody; Meltrin-beta antibody; Metalloprotease and disintegrin dendritic antigen marker antibody; MADDAM antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 protein (203-460AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
Gene References into Functions
  1. 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease. PMID: 27078193
  2. ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. PMID: 26912236
  3. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells PMID: 26823772
  4. miR-30c inhibited colon cancer cells via targeting ADAM19. PMID: 25799050
  5. four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease. PMID: 25114068
  6. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
  7. MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 PMID: 25475731
  8. ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls. PMID: 23429442
  9. Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
  10. Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma. PMID: 21239057
  11. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2. PMID: 20460109
  12. ADAM19 correlates with the progress and prognosis of endometrial carcinoma. PMID: 18458692
  13. ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation. PMID: 19727588
  14. activation by furin via one of two consecutive recognition sites PMID: 12006600
  15. investigation of proteolytic activity PMID: 12393862
  16. yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19 PMID: 12463424
  17. A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues. PMID: 15242783
  18. ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene. PMID: 15896713
  19. ADAM19 may have a modulatory role in the dysfunctional renal allograft state PMID: 16827870
  20. results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein PMID: 17112471
  21. we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer. PMID: 18714391

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed in many normal organ tissues and several cancer cell lines.
Database Links

HGNC: 197

OMIM: 603640

KEGG: hsa:8728

STRING: 9606.ENSP00000257527

UniGene: Hs.483944

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