AFF1 Antibody

Code CSB-PA010201
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
AF 4 antibody; AF 4 protein antibody; AF4 antibody; AF4-MLL antibody; AF4/FMR2 family member 1 antibody; AFF 1 antibody; AFF1 antibody; AFF1_HUMAN antibody; ALL1 fused gene from chromosome 4 antibody; ALL1-fused gene from chromosome 4 protein antibody; FEL antibody; MGC134969 antibody; MLL/AF4 antibody; MLLT2 antibody; myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 2 antibody; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2 antibody; PBM1 antibody; Pre B cell monocytic leukemia partner 1 antibody; Protein AF-4 antibody; Protein FEL antibody; Proto-oncogene AF4 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the N-terminal region of Human AF-4.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
  2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
  3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
  4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
  5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
  6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
  7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
  8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
  9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
  10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
  11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
  12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
  13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
  14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
  15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
  16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
  17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325

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Involvement in disease
A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
Subcellular Location
Protein Families
AF4 family
Database Links

HGNC: 7135

OMIM: 159557

KEGG: hsa:4299

STRING: 9606.ENSP00000378578

UniGene: Hs.480190

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