AFF1 Antibody

1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325

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HGNC: 7135

OMIM: 159557

KEGG: hsa:4299

STRING: 9606.ENSP00000378578

UniGene: Hs.480190