AGAP1 Antibody

Code CSB-PA780863
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human liver cancer tissue, hela cells, mouse lung tissue, Primary antibody: CSB-PA780863(AGAP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
Alternative Names
AGAP 1 antibody; AGAP-1 antibody; Agap1 antibody; AGAP1_HUMAN antibody; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with GTPase domain ankyrin repeat and PH domain 1 antibody; Centaurin gamma 2 antibody; Centaurin-gamma-2 antibody; CENTG2 antibody; Cnt-g2 antibody; GGAP 1 antibody; GGAP1 antibody; GTP binding and GTPase activating protein 1 antibody; GTP-binding and GTPase-activating protein 1 antibody; KIAA1099 antibody; MGC71657 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human AGAP1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Gene References into Functions
  1. The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
  2. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. PMID: 22453919
  3. overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers PMID: 12388557
  4. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase PMID: 15381706
  5. CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. PMID: 15892143
  6. The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes. PMID: 16079295
  7. AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6. PMID: 18003747

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Subcellular Location
Cytoplasm. Note=Associates with the endocytic compartment.
Protein Families
Centaurin gamma-like family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 16922

OMIM: 608651

KEGG: hsa:116987

STRING: 9606.ENSP00000307634

UniGene: Hs.435039

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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