AGAP1 Antibody

Datasheet

Code	CSB-PA780863
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human liver cancer tissue, hela cells, mouse lung tissue, Primary antibody: CSB-PA780863(AGAP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

Q9UPQ3

Target Names

AGAP1

Alternative Names

AGAP 1 antibody; AGAP-1 antibody; Agap1 antibody; AGAP1_HUMAN antibody; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with GTPase domain ankyrin repeat and PH domain 1 antibody; Centaurin gamma 2 antibody; Centaurin-gamma-2 antibody; CENTG2 antibody; Cnt-g2 antibody; GGAP 1 antibody; GGAP1 antibody; GTP binding and GTPase activating protein 1 antibody; GTP-binding and GTPase-activating protein 1 antibody; KIAA1099 antibody; MGC71657 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human AGAP1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.

Gene References into Functions

The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. PMID: 22453919
overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers PMID: 12388557
AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase PMID: 15381706
CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. PMID: 15892143
The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes. PMID: 16079295
AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6. PMID: 18003747

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Subcellular Location

Cytoplasm. Note=Associates with the endocytic compartment.

Protein Families

Centaurin gamma-like family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 16922

OMIM: 608651

KEGG: hsa:116987

STRING: 9606.ENSP00000307634

UniGene: Hs.435039

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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