ALOX15B Antibody

1. Ca(2+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT domain. PMID: 28809482
2. 15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop. PMID: 27435673
3. these results demonstrate the strict regiospecificity of h15-LOX-2 that circumscribes its role in transcellular synthesis. PMID: 27145229
4. This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2. PMID: 26918937
5. The ALOX15B gene may be associated with coronary artery disease. PMID: 24373925
6. Hpoxia-induced pulmonary vascular remodeling is associated with increased levels of 15-LO-2. PMID: 25895668
7. ALOX15 rs11568070 polymorphisms did not discriminate for the disease or its severity. PMID: 24975552
8. 15-LOX2 expression inhibits Myc-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia. PMID: 24732589
9. activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin generation PMID: 24533104
10. Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension. PMID: 24376652
11. Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain. PMID: 24497644
12. ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4, LPS and hypoxia. PMID: 22980500
13. The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity. PMID: 21951814
14. Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid. PMID: 21900394
15. In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms. PMID: 21316676
16. Results from this study suggest a 125-bp region (-157 to -33) is critical for the 15-LOX-2 promoter activity in prostate epithelial cells and cancer cells PMID: 20428779
17. a negative cell cycle regulator in normal prostate epithelial cells, but not present in prostatic neoplasms PMID: 11839751
18. 15-LOX-2 expression is lost in esophageal cancers and the induction of 15-LOX-2 can inhibit cancer cell proliferation PMID: 12659684
19. 15-LOX2 and its splice variants suppress prostate tumor development PMID: 12704195
20. Sp1 and Sp3 proteins play a physiologically important role in positively and negatively regulating the 15-LOX2 gene expression, respectively. PMID: 15247906
21. feedback mechanisms may contribute to the loss of 15-LOX-2 pathway components, which coincide with an increase in PPAR-gamma in many epithelial cancers PMID: 15799828
22. Crosstalk mechanisms exist between the 15-LOX-2 gene and peroxisome proliferator-activated receptor gamma (PPARgamma) to counterbalance expression and help explain the inverse relationship of these genes in normal prostate versus prostate cancer cells. PMID: 16682954
23. Loss of heterozygosity on 17p13 and down-regulation of ALOX15B can be used to discriminate adrenal cortex neoplasms from adrenocortical adenoma. PMID: 18156936
24. 13-(S)-hydroxyoctadecadienoic acid (13-HODE) is docked to solvent-exposed histidines of a 15-hLOX-2 homology model and found to bind well with histidine627, suggesting a potential location for the allosteric site. PMID: 19645454
25. Expression of 8S-LOX and 15S-LOX-2 suppresses CRD-BP/IMP-1 expression, resulting in inhibition of human prostate carcinoma PC-3 cell proliferation. PMID: 19661680

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HGNC: 434

OMIM: 603697

KEGG: hsa:247

STRING: 9606.ENSP00000369530

UniGene: Hs.111256