ANP32A Antibody

1. our study reveals that ANP32A dysregulation may be a critical factor contributing to acute megakaryoblastic leukemia PMID: 29269781
2. These data suggest compensatory mechanisms underlying viral Polymerase adaptation to host ANP32A independent of species-specific interactions. PMID: 28903035
3. ANP32A promoted CRC proliferation by inhibition of p38. PMID: 28731192
4. Data show that PP32 and SET/TAF-Ibeta proteins block HAT1-mediated H4 acetylation. PMID: 28977641
5. Results suggest that ANP32A is commonly increased in oral squamous cell carcinoma and ANP32A protein could act as a potential biomarker for prognosis assessment of oral cancer patients with lymph node metastasis. PMID: 26918356
6. According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival. PMID: 29106904
7. Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis. PMID: 26512887
8. High-resolution crystal structure of the leucine-rich repeat domain of the human tumour suppressor PP32A (ANP32A) has been reported. PMID: 26057796
9. ANP32A represents an essential host partner co-opted to support influenza virus replication and is a candidate host target for novel antivirals PMID: 26738596
10. conformational analysis of the C-terminal transition state of the leucine-rich repeat domain of PP32 PMID: 25902505
11. Demonstrate that HPPCn attenuated oxidative injury and fibrosis induced by ethanol feeding and that the SphK1/S1P/S1PRs signalling pathway contributes to this protective effect. PMID: 23839903
12. The HPPCn expression might be involved in the development of hepatocellular carcinoma and could be served as a promising biomarker. PMID: 20683644
13. MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. PMID: 21317927
14. pp32 interacted with STAT1 and STAT2 in an IFNB-dependent manner. PMID: 21325029
15. Data provide evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy. PMID: 21152064
16. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. PMID: 20558741
17. Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. PMID: 11830591
18. regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis PMID: 12522243
19. LANP could play a key role in neuronal development and/or neurodegeneration by its interactions with microtubule associated proteins PMID: 12807913
20. Set/TAF-Ibeta and pp32 proteins have roles as transducers of chromatin signaling by integrating chromatin hypoacetylation and transcriptional repression PMID: 15136563
21. tyrosine phosphorylation of PHAPI is accompanied by the release of PP2A from association with PHAPI, allowing increased phosphatase activity of PP2A and consequent complete dephosphorylation of the ERK kinase, MEK1/2, by 10 min and of ERK1/2 by 60 min PMID: 15247276
22. We now show pp32 increases androgen receptor-mediated transcription and the retinoblastoma protein modulates this activity. PMID: 16009334
23. The ANP32A protein is characterizing as modulators of Wnt protein signaling of Axin-1. PMID: 16169070
24. pp32 plays a repressive role by inhibiting transcription and triggering apoptosis. PMID: 16341127
25. Immunoblot detection revealed that the inhibitor I1PP2A is expressed throughout the brain, including the hippocampus, temporal cortex, parietal cortex, subcortical nuclei and brain stem. PMID: 17266954
26. LANP and ATAXN1 interact in E4F-mediated transcriptional repression. PMID: 17557114
27. These results identify pp32/PHAPI as regulator of the apoptosis response of cancer cells in vitro and in vivo, and as a predictor of survival following chemotherapy for advanced non-small-cell lung cancer. PMID: 17962813
28. Results describe the solution structure of the evolutionarily conserved N-terminal leucine-rich repeat (LRR) domain of Anp32a and model its interactions with other proteins. PMID: 18410380
29. PHAPI, CAS, and Hsp70 function together to accelerate nucleotide exchange on Apaf-1 and prevent inactive Apaf-1/cytochrome c aggregation. PMID: 18439902
30. PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. PMID: 19121999
31. ANP32A is involved in the pathogenesis of osteoarthritis of the hip. PMID: 19565487

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HGNC: 13233

OMIM: 600832

KEGG: hsa:8125

STRING: 9606.ENSP00000417864

UniGene: Hs.458747