ARHGAP10 Antibody

Code CSB-PA002012LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002012LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA002012LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARHGAP10 Polyclonal antibody
Uniprot No.
Target Names
ARHGAP10
Alternative Names
Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rho GTPase-activating protein 10 protein (542-744AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARHGAP10 Antibody (Product code: CSB-PA002012LA01HU) is Non-conjugated. For ARHGAP10 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA002012LB01HU ARHGAP10 Antibody, HRP conjugated ELISA
FITC CSB-PA002012LC01HU ARHGAP10 Antibody, FITC conjugated
Biotin CSB-PA002012LD01HU ARHGAP10 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
Gene References into Functions
  1. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
  2. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
  3. PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851
Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
Tissue Specificity
High levels of expression in heart and skeletal muscle.
Database Links

HGNC: 26099

OMIM: 609746

KEGG: hsa:79658

STRING: 9606.ENSP00000336923

UniGene: Hs.368631

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