ARHGAP26 Antibody

1. GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation. PMID: 27588930
2. We conclude that a transient interaction between Cdc42 and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism. PMID: 26446261
3. GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia. PMID: 25088035
4. ADAR1 regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR-30b-3p and miR-573 within the 3' UTR of ARHGAP26. PMID: 24067935
5. proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes PMID: 21965292
6. Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML. PMID: 21074269
7. a GTPase-activating protein that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation PMID: 21622574
8. Decreased level of GRAF transcript is associated with acute myeloid leukemia, myelodysplastic syndrome and chronic myeloid leukemia. PMID: 20704716
9. The GRAF gene was down-regulated in AML, which might play a role in the leukemogenesis. PMID: 20533268
10. The analysis of the expression pattern of the GRAF1/OPHN-1-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform. PMID: 20602808
11. abnormal GRAF methylation might be an adverse prognostic event in MDS PMID: 20374274
12. Graf residues important for the structural integrity are critical for binding RhoA and for the catalytic activity of GAP, but GTPase selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface. PMID: 18929667
13. GRAF is a negative regulator of RhoA in vivo, it acts as a GTP-ase activating protein (GAP) for RhoA and may be a downstream effector of RhoA in certain cell types. PMID: 9858476

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HGNC: 17073

OMIM: 605370

KEGG: hsa:23092

STRING: 9606.ENSP00000274498

UniGene: Hs.654668