ARHGAP32 Antibody

Datasheet

Code	CSB-PA415667LA01HU
Size	US$166
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Image	Immunofluorescence staining of SH-SY5Y cells with CSB-PA415667LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARHGAP32 Polyclonal antibody

Uniprot No.

A7KAX9

Target Names

ARHGAP32

Alternative Names

ARHGAP32 antibody; GRIT antibody; KIAA0712 antibody; RICS antibody; Rho GTPase-activating protein 32 antibody; Brain-specific Rho GTPase-activating protein antibody; GAB-associated Cdc42/Rac GTPase-activating protein antibody; GC-GAP antibody; GTPase regulator interacting with TrkA antibody; Rho-type GTPase-activating protein 32 antibody; Rho/Cdc42/Rac GTPase-activating protein RICS antibody; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling antibody; p200RhoGAP antibody; p250GAP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rho GTPase-activating protein 32 protein (130-205AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARHGAP32 Antibody (Product code: CSB-PA415667LA01HU) is Non-conjugated. For ARHGAP32 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA415667LB01HU	ARHGAP32 Antibody, HRP conjugated	ELISA
FITC	CSB-PA415667LC01HU	ARHGAP32 Antibody, FITC conjugated
Biotin	CSB-PA415667LD01HU	ARHGAP32 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:20-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.

Gene References into Functions

Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain PMID: 23226367
the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia. PMID: 22530067
These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases. PMID: 12446789
involvement in the regulation of neurite outgrowth by exerting its RhoGAP activity and that its cellular activity may be regulated through interaction with Src-like tyrosine kinases PMID: 12454018
This article analyzes Rac activation during live neutrophil chemotaxis. PMID: 12477392
RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases PMID: 12531901
is phosphorylated by Fyn in oligodendrocytes PMID: 12788081
GC-GAP may play a role in dendritic morphogenesis and also possibly in neural/glial cell proliferation PMID: 12819203
p250GAP is likely to be involved in actin reorganization in dendritic spines PMID: 12857875
Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits. PMID: 17663722
Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling. PMID: 18451111
miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity. PMID: 18577589
p250GAP may be involved in NMDA receptor activity-dependent actin reorganization in dendritic spines PMID: 12857875

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Subcellular Location

Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane.

Protein Families

PX domain-containing GAP family

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.

Database Links

HGNC: 17399

OMIM: 608541

KEGG: hsa:9743

STRING: 9606.ENSP00000310561

UniGene: Hs.440379

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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