ARHGEF17 Antibody

Code CSB-PA080066
Size US$100
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Product Details

Uniprot No.
Target Names
ARHGEF17
Alternative Names
ARHGEF17 antibody; KIAA0337 antibody; TEM4Rho guanine nucleotide exchange factor 17 antibody; 164 kDa Rho-specific guanine-nucleotide exchange factor antibody; p164-RhoGEF antibody; p164RhoGEF antibody; Tumor endothelial marker 4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human p164-RhoGEF.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
Gene References into Functions
  1. data implicate TEM4 as an essential regulator of the actin cytoskeleton that ensures proper membrane protrusion at the leading edge of migrating cells and efficient cellular migration via suppression of actomyosin contractility PMID: 23825001
  2. Interaction of the central domain of ARHGEF17 with Mps1. PMID: 26953350
  3. The rho guanine nucleotide exchange factor 17 is drastically alter the effect of cGMP/cGK involving signaling pathways on RhoA-activated downstream effectors. PMID: 23195829
  4. TEM4 contains a novel actin binding domain and binding to actin is essential for TEM4 subcellular localization and activity. PMID: 22911862
  5. a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart PMID: 12071859
  6. Identification of ARHGEF17, mutations in melanoma. PMID: 18677770

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Tissue Specificity
Highly expressed in the heart.
Database Links

HGNC: 21726

KEGG: hsa:9828

STRING: 9606.ENSP00000263674

UniGene: Hs.533719

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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