ARL4C Antibody

Datasheet

Code	CSB-PA002086LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA002086LA01HU at dilution of 1:100 Immunofluorescence staining of PC-3 cells with CSB-PA002086LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARL4C Polyclonal antibody

Uniprot No.

P56559

Target Names

ARL4C

Alternative Names

ADP ribosylation factor like 4C antibody; ADP ribosylation factor like 7 antibody; ADP-ribosylation factor-like protein 4C antibody; ADP-ribosylation factor-like protein 7 antibody; ADP-ribosylation factor-like protein LAK antibody; Arl4c antibody; ARL4C_HUMAN antibody; ARL7 antibody; LAK antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ADP-ribosylation factor-like protein 4C protein (2-192AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARL4C Antibody (Product code: CSB-PA002086LA01HU) is Non-conjugated. For ARL4C Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002086LB01HU	ARL4C Antibody, HRP conjugated	ELISA
FITC	CSB-PA002086LC01HU	ARL4C Antibody, FITC conjugated
Biotin	CSB-PA002086LD01HU	ARL4C Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.

Gene References into Functions

We demonstrate that ARL4C knockdown likely attenuates osteogenesis of hASCs through inhibition of the Wnt signaling pathway. These results provide new insights into the mechanisms of osteogenic differentiation and provide a potential molecular target for bone tissue engineering. PMID: 29432742
ARL4C is expressed due to hypomethylation in the 3'-UTR for certain types of cancers and that ARL4C methylation status is involved in squamous cell carcinoma cell function. PMID: 27835592
Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis. PMID: 28053143
Results indicated that overexpression of Arl4c might contribute to the tumorigenesis and might play a pivotal role in the progression of CRC. PMID: 26756615
Arl4c is involved in tumorigenesis and might represent a novel therapeutic target for suppressing proliferation and invasion of colorectal and lung cancer cells. PMID: 25486429
Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form. PMID: 17398095
ARL7 might modulate the intracellular vesicular transport via interaction with microtubules. PMID: 19409876

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Subcellular Location

Cell projection, filopodium. Cell membrane. Cytoplasm.

Protein Families

Small GTPase superfamily, Arf family

Tissue Specificity

Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.

Database Links

HGNC: 698

OMIM: 604787

KEGG: hsa:10123

STRING: 9606.ENSP00000375057

UniGene: Hs.111554

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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