ARR3 Antibody

Code CSB-PA002133GA01HU
Size US$685
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Product Details

Uniprot No. P36575
Target Names ARR3
Alternative Names ARR3 antibody; ARR4 antibody; ARRC_HUMAN antibody; Arrestin 3 retinal antibody; Arrestin 3 retinal (X-arrestin) antibody; Arrestin 4 antibody; Arrestin-C antibody; ARRX antibody; C arrestin antibody; C-arrestin antibody; CAR antibody; cArr antibody; Cone arrestin antibody; Retinal cone arrestin 3 antibody; Retinal cone arrestin-3 antibody; X arrestin antibody; X-arrestin antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Human ARR3
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
Gene References into Functions
  1. These data suggest that heterozygous mutations in ARR3 might be responsible for X-linked female-limited early onset high myopia in the three families, a pattern contrary to the standard X-linked recessive trait. PMID: 27829781
  2. In the cell membrane, arrestin-3 dissociates quickly and almost completely from the Beta2-adrenoceptor. PMID: 25425623
  3. Identification of receptor binding-induced conformational changes in non-visual arrestins. PMID: 24867953
  4. The 25-amino acid N-domain element of arrestin 3 has the highest affinity for JNK3alpha2, suggesting that it is the key site for JNK3alpha2 docking. PMID: 24412749
  5. arrestin-3 regulates the activity of multiple JNK isoforms, suggesting that it might play a role in survival and apoptosis of all cell types. PMID: 24292834
  6. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. PMID: 22523077
  7. PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking. PMID: 22242112
  8. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner PMID: 21203429
  9. two non-visual arrestins, arrestin2 and arrestin3, localize to the centrosome, a key organelle involved in microtubule nucleation and bipolar mitotic spindle assembly PMID: 20056609
  10. Regulation of arrestin-3 phosphorylation by casein kinase II. PMID: 11877451
  11. The light-dependent translocation of cone arrestin suggests a role in light-dark adaptation of cones. PMID: 12824223
  12. association of arrestin-3 with the FSHR is dependent on receptor phosphorylation, however phosphorylation of the third intracellular loop residues is not needed for arrestin-3 association. PMID: 12850288
  13. Autoimmunity to this antigen and retinal vasculitis is not altered in patients with Behcet's disease PMID: 12918707
  14. Arrestin in all conformations binds JNK3 comparably, whereas Mdm2 preferentially binds cone arrestin 'frozen' in the basal state. PMID: 17680991
  15. Arrestin 3 but not arrestin 2 is required for internalization of C-C chemokine receptor CCR7 when bound to C-C chemokine ligand CCL19. In contrast, arrestins are not required for internalization of CCR7/CCL21. PMID: 18802075
  16. the molecular interactions of arrestin2 and arrestin3 and their individual domains with the components of the two MAPK cascades, ASK1-MKK4-JNK3 and c-Raf-1-MEK1-ERK2 PMID: 19001375

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Protein Families Arrestin family
Tissue Specificity Inner and outer segments, and the inner plexiform regions of the retina.
Database Links

HGNC: 710

OMIM: 301770

KEGG: hsa:407

STRING: 9606.ENSP00000311538

UniGene: Hs.308

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