ARR3 Antibody

1. These data suggest that heterozygous mutations in ARR3 might be responsible for X-linked female-limited early onset high myopia in the three families, a pattern contrary to the standard X-linked recessive trait. PMID: 27829781
2. In the cell membrane, arrestin-3 dissociates quickly and almost completely from the Beta2-adrenoceptor. PMID: 25425623
3. Identification of receptor binding-induced conformational changes in non-visual arrestins. PMID: 24867953
4. The 25-amino acid N-domain element of arrestin 3 has the highest affinity for JNK3alpha2, suggesting that it is the key site for JNK3alpha2 docking. PMID: 24412749
5. arrestin-3 regulates the activity of multiple JNK isoforms, suggesting that it might play a role in survival and apoptosis of all cell types. PMID: 24292834
6. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. PMID: 22523077
7. PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking. PMID: 22242112
8. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner PMID: 21203429
9. two non-visual arrestins, arrestin2 and arrestin3, localize to the centrosome, a key organelle involved in microtubule nucleation and bipolar mitotic spindle assembly PMID: 20056609
10. Regulation of arrestin-3 phosphorylation by casein kinase II. PMID: 11877451
11. The light-dependent translocation of cone arrestin suggests a role in light-dark adaptation of cones. PMID: 12824223
12. association of arrestin-3 with the FSHR is dependent on receptor phosphorylation, however phosphorylation of the third intracellular loop residues is not needed for arrestin-3 association. PMID: 12850288
13. Autoimmunity to this antigen and retinal vasculitis is not altered in patients with Behcet's disease PMID: 12918707
14. Arrestin in all conformations binds JNK3 comparably, whereas Mdm2 preferentially binds cone arrestin 'frozen' in the basal state. PMID: 17680991
15. Arrestin 3 but not arrestin 2 is required for internalization of C-C chemokine receptor CCR7 when bound to C-C chemokine ligand CCL19. In contrast, arrestins are not required for internalization of CCR7/CCL21. PMID: 18802075
16. the molecular interactions of arrestin2 and arrestin3 and their individual domains with the components of the two MAPK cascades, ASK1-MKK4-JNK3 and c-Raf-1-MEK1-ERK2 PMID: 19001375

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HGNC: 710

OMIM: 301770

KEGG: hsa:407

STRING: 9606.ENSP00000311538

UniGene: Hs.308