ARV1 Antibody

Datasheet

Code	CSB-PA867134EA01HU
Size	US$166
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Image	Immunofluorescent analysis of A2780 cells using CSB-PA867134EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARV1 Polyclonal antibody

Uniprot No.

Q9H2C2

Target Names

ARV1

Alternative Names

ARV1; HT035; Protein ARV1; hARV1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein ARV1 protein (1-143AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARV1 Antibody (Product code: CSB-PA867134EA01HU) is Non-conjugated. For ARV1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA867134EB01HU	ARV1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA867134EC01HU	ARV1 Antibody, FITC conjugated
Biotin	CSB-PA867134ED01HU	ARV1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.

Gene References into Functions

In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy PMID: 27270415
A novel function for Arv1 in regulation of cell division through promotion of the contractile actomyosin ring, which is independent of its lipid transporter activity. PMID: 27104745
Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Delta mutant. Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. PMID: 26460143
These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism. PMID: 24273168
Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism PMID: 20663892
ARV1 plays a role in sphingolipid metabolism and complements yeast ARV1 PMID: 12145310

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Involvement in disease

Epileptic encephalopathy, early infantile, 38 (EIEE38)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

ARV1 family

Tissue Specificity

Ubiquitous. Highly expressed in liver and adipose.

Database Links

HGNC: 29561

OMIM: 611647

KEGG: hsa:64801

STRING: 9606.ENSP00000312458

UniGene: Hs.275736

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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