ARV1 Antibody

Code CSB-PA867134EA01HU
Size US$166
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  • Immunofluorescent analysis of A2780 cells using CSB-PA867134EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARV1 Polyclonal antibody
Uniprot No.
Target Names
ARV1
Alternative Names
ARV1; HT035; Protein ARV1; hARV1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein ARV1 protein (1-143AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARV1 Antibody (Product code: CSB-PA867134EA01HU) is Non-conjugated. For ARV1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA867134EB01HU ARV1 Antibody, HRP conjugated ELISA
FITC CSB-PA867134EC01HU ARV1 Antibody, FITC conjugated
Biotin CSB-PA867134ED01HU ARV1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.
Gene References into Functions
  1. In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy PMID: 27270415
  2. A novel function for Arv1 in regulation of cell division through promotion of the contractile actomyosin ring, which is independent of its lipid transporter activity. PMID: 27104745
  3. Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Delta mutant. Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. PMID: 26460143
  4. These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism. PMID: 24273168
  5. Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism PMID: 20663892
  6. ARV1 plays a role in sphingolipid metabolism and complements yeast ARV1 PMID: 12145310

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Involvement in disease
Epileptic encephalopathy, early infantile, 38 (EIEE38)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
ARV1 family
Tissue Specificity
Ubiquitous. Highly expressed in liver and adipose.
Database Links

HGNC: 29561

OMIM: 611647

KEGG: hsa:64801

STRING: 9606.ENSP00000312458

UniGene: Hs.275736

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