ASCC3 Antibody

Datasheet

Code	CSB-PA002198ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002198ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002198ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA002198ESR1HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ASCC3 Polyclonal antibody

Uniprot No.

Q8N3C0

Target Names

ASCC3

Alternative Names

Activating signal cointegrator 1 complex subunit 3 antibody; ASC-1 complex subunit p200 antibody; ASC-1 complex subunit p200-KD subunit antibody; ASC1p200 antibody; ascc3 antibody; ATP binding 1 antibody; B630009I04Rik antibody; dJ121G13.4 antibody; DJ467N11.1 antibody; HELC1_HUMAN antibody; HELIC1 antibody; Helicase antibody; helicase; ATP binding 1 antibody; p200 antibody; RNA helicase family antibody; RNAH antibody; RP1-121G13.4 antibody; Trip4 complex subunit p200 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.

Gene References into Functions

UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. PMID: 28215706
ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B. PMID: 26536629
Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses. PMID: 23781071
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184

Subcellular Location

Nucleus. Nucleus speckle. Cytoplasm, cytosol.

Protein Families

Helicase family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 18697

OMIM: 614217

KEGG: hsa:10973

STRING: 9606.ENSP00000358159

UniGene: Hs.486031

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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