ATG16L2 Antibody

Datasheet

Code	CSB-PA843310HA01HU
Size	US$166
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Image	IHC image of CSB-PA843310HA01HU diluted at 1:700 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA843310HA01HU diluted at 1:700 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescent analysis of HepG2 cells using CSB-PA843310HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATG16L2 Polyclonal antibody

Uniprot No.

Q8NAA4

Target Names

ATG16L2

Alternative Names

A16L2_HUMAN antibody; APG16-like 2 antibody; ATG16 autophagy related 16-like 2 antibody; ATG16B antibody; Atg16l2 antibody; autophagy related 16-like 2 (S. cerevisiae) antibody; Autophagy-related protein 16-2 antibody; WD repeat-containing protein 80 antibody; WDR80 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Autophagy-related protein 16-2 protein (262-348AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ATG16L2 Antibody (Product code: CSB-PA843310HA01HU) is Non-conjugated. For ATG16L2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA843310HB01HU	ATG16L2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA843310HC01HU	ATG16L2 Antibody, FITC conjugated
Biotin	CSB-PA843310HD01HU	ATG16L2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.

Gene References into Functions

ATG16L2 is a susceptibility gene for Crohn's disease in the Chinese population. The rs11235604 single nucleotide polymorphism is remarkably associated with downregulation of the expression of ATG16L2. PMID: 27611316
A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
Atg16L2 may play an important role in autophagy of T cells and serve as a potential biomarker to predict clinical relapse of Multiple sclerosis PMID: 24406150
Three novel risk loci including ATG16L2 were discovered by genome-wide association study in the Korean Crohn's disease population, of which two showed patterns of association in the International Inflammatory Bowel Disease Genetics Consortium dataset. PMID: 23850713

Subcellular Location

Cytoplasm, cytosol.

Protein Families

WD repeat ATG16 family

Database Links

HGNC: 25464

KEGG: hsa:89849

STRING: 9606.ENSP00000326340

UniGene: Hs.653186

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Autophagy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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