ATP5F1C Antibody

Datasheet

Code	CSB-PA002353LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002353LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATP5C1 Polyclonal antibody

Uniprot No.

P36542

Target Names

ATP5C1

Alternative Names

ATP synthase gamma chain; mitochondrial antibody; ATP synthase subunit gamma antibody; ATP synthase subunit gamma; mitochondrial antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma polypeptide 1 antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma subunit antibody; ATP5C 1 antibody; ATP5C antibody; ATP5C1 antibody; ATP5CL1 antibody; ATPG_HUMAN antibody; F ATPase gamma subunit antibody; F-ATPase gamma subunit antibody; mitochondrial antibody; Mitochondrial ATP synthase; gamma subunit 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ATP synthase subunit gamma, mitochondrial protein (156-266AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ATP5F1C Antibody (Product code: CSB-PA002353LA01HU) is Non-conjugated. For ATP5F1C Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002353LB01HU	ATP5F1C Antibody, HRP conjugated	ELISA
FITC	CSB-PA002353LC01HU	ATP5F1C Antibody, FITC conjugated
Biotin	CSB-PA002353LD01HU	ATP5F1C Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene References into Functions

Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation. PMID: 29499186
These results demonstrated that the 5'-AGUUCCA-3' immediately downstream from ESE is a muscle-specific exonic splicing silencer (MS-ESS) responsible for exclusion of exon 9 in vivo and in vitro PMID: 11744705
A report on the mechanism of exon skipping regulated by Fox-1, using the hF1gamma gene as a model system. PMID: 17686786

Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Protein Families

ATPase gamma chain family

Tissue Specificity

Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta

Database Links

HGNC: 833

OMIM: 108729

KEGG: hsa:509

STRING: 9606.ENSP00000349142

UniGene: Hs.271135

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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