ATP8A1 Antibody

Code CSB-PA896697LA01HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA896697LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA896697LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA896697LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ATP8A1 Polyclonal antibody
Uniprot No.
Target Names
ATP8A1
Alternative Names
ATP8A1 antibody; ATPIAPhospholipid-transporting ATPase IA antibody; EC 7.6.2.1 antibody; ATPase class I type 8A member 1 antibody; Chromaffin granule ATPase II antibody; P4-ATPase flippase complex alpha subunit ATP8A1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phospholipid-transporting ATPase IA protein (448-545AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ATP8A1 Antibody (Product code: CSB-PA896697LA01HU) is Non-conjugated. For ATP8A1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA896697LB01HU ATP8A1 Antibody, HRP conjugated ELISA
FITC CSB-PA896697LC01HU ATP8A1 Antibody, FITC conjugated
Biotin CSB-PA896697LD01HU ATP8A1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
Gene References into Functions
  1. Knockdown of ATP8A1 (a recycling endosome phosphatidlyserine-flippase) suppresses nuclear localization of YAP and YAP-dependent transcription. ATP8A1 knockdown increases the phosphorylated (activated) form of Lats1 that phosphorylates and inactivates YAP. PMID: 29093443
  2. The increased level of intracellular ATP8A1 protein attenuated the inhibitor role of miR-140-3p in the growth and mobility of NSCLC cell. PMID: 26415732
  3. Depletion of ATP8A1 impaired the asymmetric transbilayer distribution of phosphatidylserine in recycling endosomes, dissociated EHD1 from recycling endosomes, and generated aberrant endosomal tubules that appear resistant to fission. PMID: 25595798
  4. the phospholipid flippase complex of ATP8A1 and CDC50A proteins has a role in cell migration PMID: 23269685
  5. APLT has a role in macrophage-induced nitrosylation/oxidation plays an important role in cell clearance PMID: 17229723

Show More

Hide All

Subcellular Location
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus.
Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Tissue Specificity
Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal musc
Database Links

HGNC: 13531

OMIM: 609542

KEGG: hsa:10396

STRING: 9606.ENSP00000371084

UniGene: Hs.435052

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*