ATP8A2 Antibody

Datasheet

Code	CSB-PA865134LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA865134LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA865134LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATP8A2 Polyclonal antibody

Uniprot No.

Q9NTI2

Target Names

ATP8A2

Alternative Names

AT8A2_HUMAN antibody; ATP antibody; Atp8a2 antibody; ATPase aminophospholipid transporter class I type 8A member 2 antibody; ATPase aminophospholipid transporter like class I type 8A member 2 antibody; ATPase class I type 8A member 2 antibody; ATPase phospholipid transporting 8A2 antibody; ATPIB antibody; CAMRQ4 antibody; EC=3.6.3.1 antibody; IB antibody; ML-1 antibody; ML1 antibody; P4 ATPase flippase complex alpha subunit ATP8A2 antibody; Probable phospholipid-transporting ATPase IB antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ATP8A2 Antibody (Product code: CSB-PA865134LA01HU) is Non-conjugated. For ATP8A2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA865134LB01HU	ATP8A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865134LC01HU	ATP8A2 Antibody, FITC conjugated
Biotin	CSB-PA865134LD01HU	ATP8A2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

Gene References into Functions

Study describes a new ATP8A2 gene mutations associated with a novel syndrome that includes encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy. The data expand both the genetic and phenotypic spectrum associated with ATP8A2 gene mutations. PMID: 27679995
ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait. PMID: 22892528
CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2 PMID: 21454556
P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes PMID: 19778899

Involvement in disease

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)

Subcellular Location

Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.

Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Tissue Specificity

Strongly expressed in the brain, cerebellum, retina and testis.

Database Links

HGNC: 13533

OMIM: 605870

KEGG: hsa:51761

STRING: 9606.ENSP00000371070

UniGene: Hs.444957

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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