ATXN1L Antibody, Biotin conjugated

Code CSB-PA002440LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ATXN1L Polyclonal antibody
Uniprot No.
Target Names
ATXN1L
Alternative Names
ATXN1L antibody; BOAT antibody; BOAT1Ataxin-1-like antibody; Brother of ataxin-1 antibody; Brother of ATXN1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ataxin-1-like protein (183-463AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
Gene References into Functions
  1. The ATXN1L-CIC-ETS transcription factor axis as a mediator of resistance to MAPKi. PMID: 28178529
  2. Both ATXN1 and BOAT1 bind to the promoter region of Hey1 and inhibit the transcriptional output of Notch through direct interactions with CBF1, a transcription factor that is crucial for the Notch pathway. PMID: 21475249
  3. Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals PMID: 16121196
Subcellular Location
Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Protein Families
ATXN1 family
Tissue Specificity
Expressed in cerebellum and cerebral cortex.
Database Links

HGNC: 33279

OMIM: 614301

KEGG: hsa:342371

STRING: 9606.ENSP00000415822

UniGene: Hs.743239

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