Acetyl-HIST1H1A (K21) Antibody

Code CSB-PA010376PA21acHU
Size US$175
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  • Immunofluorescent analysis of HepG2 cells (sodium butyrate, 30 mM, 4h) using CSB-PA010376PA21acHU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HIST1H1A Polyclonal antibody
Uniprot No.
Target Names
HIST1H1A
Alternative Names
H1-1 antibody; H1F1 antibody; HIST1H1A antibody; Histone H1.1 antibody; Histone H1a antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence around site of Acetyl-Lys (21) derived from Human Histone H1.1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Gene References into Functions
  1. Data indicate that IgGs possessing an affinity to histone H1 were isolated by affinity chromatography and size exclusion chromatography. PMID: 28361854
  2. Proper binding of histone H1.1 to chromatin is determined by the simultaneous and synergistic binding of its folded wing helix domain -C-terminal domains to the nucleosome. PMID: 26182371
  3. HIST1 cluster PcG methylation has a role in epigenesis in acute myeloid leukemia PMID: 25482132
  4. Results suggest the potential for histone H1 phosphorylation at threonine 146 as a clinical biomarker in breast cancer. PMID: 24601643
  5. fluorescence recovery after photobleaching analyses suggested that TAF-I beta enhances the dissociation of H1.1 from chromatin in the living cell PMID: 21940793
  6. Data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1 through its first acidic stretch (residues 120-132). PMID: 21425800
  7. the C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo PMID: 14985337

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Subcellular Location
Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
Protein Families
Histone H1/H5 family
Database Links

HGNC: 4715

OMIM: 142709

KEGG: hsa:3024

STRING: 9606.ENSP00000244573

UniGene: Hs.150206

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