B4GALNT2 Antibody

Datasheet

Code	CSB-PA854161LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA854161LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) B4GALNT2 Polyclonal antibody

Uniprot No.

Q8NHY0

Target Names

B4GALNT2

Alternative Names

4 N-acetylgalactosaminyltransferase 2 antibody; 4-GalNAc transferase antibody; 4-N-acetylgalactosaminyltransferase antibody; B4GALNT2 antibody; B4GALT antibody; B4GN2_HUMAN antibody; Beta 1,4 N-acetylgalactosaminyltransferase/betal,4 GalNAcT/Sda-GalNAcT antibody; Beta-1 antibody; beta-1,4-N-acetyl-galactosaminyl transferase 2 antibody; beta-4-N-acetylgalactosaminyltransferase antibody; CT-GalNAc transferase antibody; GALGT2 antibody; Sd(a) beta-1 antibody; sda beta-1,4-GalNAc transferase antibody; UDP-GalNAc:Neu5Aca2-3Galb-R b1 antibody; UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase antibody; UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Beta-1,4 N-acetylgalactosaminyltransferase 2 protein (301-566AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The B4GALNT2 Antibody (Product code: CSB-PA854161LA01HU) is Non-conjugated. For B4GALNT2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA854161LB01HU	B4GALNT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA854161LC01HU	B4GALNT2 Antibody, FITC conjugated
Biotin	CSB-PA854161LD01HU	B4GALNT2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.

Gene References into Functions

B4GALNT2 overexpression prevented the infection of every avian influenza virus strain tested, including the H5, H9, and H7 subtypes, which have previously caused disease in humans. PMID: 28813663
In normal colon samples a significant relationship between sLe(x) expression and the ratio between FUT6/B4GALNT2 activities exists, demonstrating for the first time a role for B4GALNT2 in sLe(x) inhibition in vivo. PMID: 24953560
These experiments demonstrate successful transduction of rhesus macaque muscle with rAAVrh74.MCK.GALGT2 after vascular delivery and induction of molecular changes thought to be therapeutic in several forms of muscular dystrophy. PMID: 24145553
molecular cloning; cDNA predicts a 566 aa protein showing 66.6% and 39% identity with mouse CT beta4GalNAc-T and human GM2/GD2 synthase PMID: 14688233
A putative CpG island encompassing the promoter and exon 1 regions in the human Sd(a) beta4GalNAcT-II gene was identified. PMID: 17965433
Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes PMID: 18485915

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 2 family

Tissue Specificity

Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum.

Database Links

HGNC: 24136

OMIM: 111730

KEGG: hsa:124872

STRING: 9606.ENSP00000300404

UniGene: Hs.374679

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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