BAZ2B Antibody

Code CSB-PA883427LA01HU
Size US$166
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  • IHC image of CSB-PA883427LA01HU diluted at 1:800 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA883427LA01HU diluted at 1:800 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA883427LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BAZ2B Polyclonal antibody
Uniprot No.
Target Names
BAZ2B
Alternative Names
BAZ2B antibody; BAZ2B_HUMAN antibody; Bromodomain adjacent to zinc finger domain 2B antibody; Bromodomain adjacent to zinc finger domain protein 2B antibody; DKFZp434H071 antibody; DKFZp762I0516 antibody; FLJ45644 antibody; hWALp4 antibody; OTTHUMP00000162897 antibody; OTTHUMP00000162898 antibody; WALp4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Bromodomain adjacent to zinc finger domain protein 2B protein (139-240AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The BAZ2B Antibody (Product code: CSB-PA883427LA01HU) is Non-conjugated. For BAZ2B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA883427LB01HU BAZ2B Antibody, HRP conjugated ELISA
FITC CSB-PA883427LC01HU BAZ2B Antibody, FITC conjugated
Biotin CSB-PA883427LD01HU BAZ2B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
IF 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI. Involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1.
Gene References into Functions
  1. Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may therefore act as a cellular mechanism to transiently tune BAZ2B histone-binding affinity. PMID: 28864776
Subcellular Location
Nucleus.
Protein Families
WAL family
Tissue Specificity
Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.
Database Links

HGNC: 963

OMIM: 605683

KEGG: hsa:29994

STRING: 9606.ENSP00000376534

UniGene: Hs.470369

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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