BCDIN3D Antibody

Code CSB-PA767206LA01HU
Size US$166
Order now
The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BCDIN3D Polyclonal antibody
Uniprot No.
Target Names
BCDIN3D
Alternative Names
BCDIN3 domain containing antibody; BCDIN3 domain-containing protein antibody; BCDIN3D antibody; BN3D2_HUMAN antibody; Probable methyltransferase BCDIN3D antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pre-miRNA 5\'-monophosphate methyltransferase protein (1-292AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The BCDIN3D Antibody (Product code: CSB-PA767206LA01HU) is Non-conjugated. For BCDIN3D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA767206LB01HU BCDIN3D Antibody, HRP conjugated ELISA
FITC CSB-PA767206LC01HU BCDIN3D Antibody, FITC conjugated
Biotin CSB-PA767206LD01HU BCDIN3D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
Gene References into Functions
  1. BCDIN3D might serve as an important prognostic factor for triple-negative breast cancer PMID: 27259993
  2. BCDIN3D acts as a cytoplasmic tRNAHis-specific 5-methylphosphate capping enzyme. PMID: 28119416
  3. Human BCDIN3D monomethylates the 5'-monophosphate of cytoplasmic tRNAHis in vitro. In BCDN3D-knockout cells, established byCRISPR/Cas9 editing, the methyl moiety at the 5'-monophosphate of cytoplasmic tRNAHis is lost, and the exogenous expression of BCDIN3D in the knockout cells restores the modification in cytoplasmic tRNAHis. PMID: 28119416
  4. BCDIN3D depletion leads to lower pre-miR-145 and concomitantly increased mature miR-145 levels in breast cancer cells, which suppresses their tumorigenic phenotypes. PMID: 23063121
Subcellular Location
Cytoplasm.
Protein Families
Methyltransferase superfamily
Database Links

HGNC: 27050

KEGG: hsa:144233

STRING: 9606.ENSP00000335201

UniGene: Hs.142736

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*