BEX1 Antibody

1. BEX1 was downregulated in esophageal squamous cell cancer (ESCC) tissues compared to adjacent normal tissues, and low BEX1 expression was significantly associated with larger tumor volume, advanced clinical, and poor survival in patients with ESCC. PMID: 30132532
2. BEX1 functions as an mRNA-dependent effector that augments pathology-promoting gene expression during heart failure. PMID: 29192139
3. loss of BEX1 expression in FLT3-ITD driven AML potentiates oncogenic signaling and leads to decreased overall survival PMID: 26046670
4. Our results revealed an interaction between BEX1 and BCL-2 and a novel mechanism of imatinib resistance mediated by the BEX1/BCL-2 pathway. PMID: 24626299
5. Bex family members play important roles in the formation of protein network hubs. PMID: 25612294
6. Epigenetic inactivation of BEX1 supports its role as a candidate tumour suppressor gene in intracranial ependymoma PMID: 24333734
7. Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. PMID: 23362108
8. This new human gene is mapped to the X chromosome and has an expression pattern of a spermatogenesis-related gene. PMID: 11989783
9. Two novel brain expressed genes, BEX1 and BEX2 are identified; they are silenced in all glioma specimens and exhibit extensive promoter hypermethylation. PMID: 16818640
10. expression of hBex1 in leukemic cells is a novel mechanism by which chemoresistance is achieved and suggests that hBex1 is a potential molecular target for the development of novel leukemia treatments PMID: 19028701

Show More

Hide All

HGNC: 1036

OMIM: 300690

KEGG: hsa:55859

STRING: 9606.ENSP00000361813

UniGene: Hs.334370