BICC1 Antibody

1. The authors demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where also the PIC and eIF4F components were shown to localize in mammalian cells. PMID: 28450740
2. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
3. Suggest allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders. PMID: 26440730
4. Results provide some support for the involvement of BICC1 and PCLO in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes PMID: 26391493
5. findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior PMID: 25178406
6. identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels PMID: 24789909
7. Polymorphisms in intron 2 of BICC1 are associated with its expression and bone mineral density (BMD) PMID: 24789909
8. The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes. PMID: 22910460
9. The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt inhibitory activity. The point mutation in the SAM domain results in a 22% loss of activity. PMID: 21922595

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HGNC: 19351

OMIM: 601331

KEGG: hsa:80114

STRING: 9606.ENSP00000362993

UniGene: Hs.100261