BICD2 Antibody, FITC conjugated

1. BICD2 facilitates infection by promoting the trafficking of viral cores to the nucleus, thereby promoting nuclear entry of the viral genome and infection PMID: 29180435
2. BICD2 missense mutations were identified in patients with severe muscular atrophy with arthrogryposis and asymptomatic individuals with subclinical features. PMID: 28635954
3. Data suggest that BICD1 and BICD2 are highly expressed in the nervous system during development and are important in neuronal homeostasis. [REVIEW] PMID: 28215293
4. results reveal that dominant mutations in BICD2 hyperactivate DDB motility and suggest that an imbalance of minus versus plus end-directed microtubule motility in neurons may underlie spinal muscular atrophy. PMID: 28883039
5. These findings give further insight into the clinical and pathoanatomical consequences of BICD2 mutations. PMID: 26998597
6. several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells PMID: 25962623
7. the features of BICD2 spinal muscular atrophy, lower extremity predominant are consistent with a pathological process that preferentially affects lumbar lower motor neurons PMID: 25497877
8. This study identified BICD3 significantly associated loci with a biologically plausible role in schizophrenia. PMID: 24507884
9. Mutations in BICD2 cause congenital autosomal-dominant spinal muscular atrophy and massive Golgi fragmentation in affected cells. PMID: 23664116
10. BICD2 mutations cause non-5q linked spinal muscular atrophy in humans PMID: 23664119
11. Disease causing mutations resulting in amino acid substitutions in two binding regions of BICD2 increase its binding affinity for the cytoplasmic dynein-dynactin complex. PMID: 23664120
12. Data suggest that ASUN promotes perinuclear enrichment of dynein at G2/M that facilitates BICD2- and CENP-F-mediated anchoring of dynein to nuclear pore complexes. PMID: 23097494
13. isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2 PMID: 11864968

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HGNC: 17208

OMIM: 609797

KEGG: hsa:23299

STRING: 9606.ENSP00000349351

UniGene: Hs.436939