BLCAP Antibody

Code CSB-PA006743
Size US$100
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Product Details

Uniprot No.
Target Names
BLCAP
Alternative Names
BLCAP; BC10; Bladder cancer-associated protein; Bladder cancer 10 kDa protein; Bc10
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Bc10.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IF, ELISA
Recommended Dilution
Application Recommended Dilution
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
Gene References into Functions
  1. Upregulated miR-9-3p has a positive role in human MTC progression by regulating the growth and apoptosis of cancer cells via targeting BLCAP. PMID: 27938505
  2. Our findings reveal that A-to-I RNA editing events alter the genetically coded amino acid in BLCAP YXXQ motif, which drive the progression of cervical carcinogenesis through regulating STAT3 signaling pathway. PMID: 28455960
  3. data indicates that Blcap is a novel Stat3 interaction partner and suggests a role for Blcap in the Stat3-mediated progression of precancerous lesions to invasive tumors of the bladder PMID: 29190807
  4. the functional association of BLCAP and Rb1 might play important roles in proliferation and apoptosis of HeLa cells. PMID: 26986503
  5. Data show that the RNA-edited bladder cancer associated protein (BLCAP) gene may stably promote cell proliferation. PMID: 25499081
  6. Immunoexpression analysis and prognostic value of BLCAP in breast cancer PMID: 23049907
  7. observed a general decrease in BLCAP-editing level in astrocytomas, bladder cancer and colorectal cancer when compared with the related normal tissues PMID: 19908260
  8. Data show that loss of BLCAP expression is associated with tumor progression. PMID: 19783793
  9. might be a potential tumor suppressor gene in cervical carcinoma. PMID: 16675915
  10. BLCAP may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of p53 and NF-kappaB. PMID: 17031575
  11. Blcap is imprinted in mouse and human brain, but not in other mouse tissues. PMID: 18836209

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
BLCAP family
Tissue Specificity
Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
Database Links

HGNC: 1055

OMIM: 613110

KEGG: hsa:10904

STRING: 9606.ENSP00000362637

UniGene: Hs.472651

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