BOC Antibody

Code CSB-PA866299ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA866299ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866299ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BOC Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
BOC antibody; UNQ604/PRO1190Brother of CDO antibody; Protein BOC antibody
Raised in
Species Reactivity
Recombinant Human Brother of CDO protein (1-125AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
Gene References into Functions
  1. we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays. PMID: 28677295
  2. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. PMID: 27871935
  3. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype PMID: 28915250
  4. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
  5. Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm. PMID: 20053908
  6. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
  7. Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. PMID: 16647304
  8. BOC, along with CDO, defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO form a putative receptor complex that stimulates differentiation of myoblasts. PMID: 11782431

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact.
Tissue Specificity
Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
Database Links

HGNC: 17173

OMIM: 608708

KEGG: hsa:91653

STRING: 9606.ENSP00000347546

UniGene: Hs.591318

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