Name: BOK Antibody
Brand: CUSABIO
SKU: CSB-PA892353LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BOK Polyclonal antibody

Uniprot No.

Q9UMX3

Target Names

BOK

Alternative Names

Bcl 2 related ovarian killer protein antibody; Bcl-2-like protein 9 antibody; Bcl-2-related ovarian killer protein antibody; BCL2 related ovarian killer antibody; Bcl2-L-9 antibody; BCL2L9 antibody; BOK antibody; BOK_HUMAN antibody; BOKL antibody; Hbok antibody; MGC4631 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bcl-2-related ovarian killer protein (15-103AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BOK Antibody (Product code: CSB-PA892353LA01HU) is Non-conjugated. For BOK Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA892353LB01HU	BOK Antibody, HRP conjugated	ELISA
FITC	CSB-PA892353LC01HU	BOK Antibody, FITC conjugated
Biotin	CSB-PA892353LD01HU	BOK Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner. In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response. Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release. In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation. Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation. In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1.; Pro-apoptotic molecule exerting its function through the mitochondrial pathway.

Gene References into Functions

Loss of BOK is associated with non-small-cell lung carcinoma. PMID: 28744854
Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40) homolog, subfamily B, member 12) PMID: 28536268
Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT) but is not affected by its antisense transcript. PMID: 24806027
First evidence for a key role of the BOK-MCL1 system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 balance toward the build-up of isoforms that triggers placental autophagy. PMID: 24113155
Bok may govern IP3R cleavage and activity during apoptosis. PMID: 23884412
Data conclude that Mtd-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd found in PE may contribute to increased trophoblast proliferation. PMID: 19942931
BOK and NOXA are essential mediators of p53-dependent apoptosis PMID: 15102863
A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia. PMID: 15775999
Studies showed that hBok was distributed in both the cytosol and intracellular membranes of healthy cells. PMID: 15868100
a link between the apoptotic activity and nuclear localization of a pro-apoptotic Bok PMID: 16302269
Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family PMID: 16772296
BOKAS is a natural antisense transcript that regulates the pro-apoptotic activity of human Bok PMID: 19287972

Hide All

Subcellular Location

[Isoform 1]: Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Membrane.; [Isoform 2]: Membrane. Cytoplasm.

Protein Families

Bcl-2 family

Tissue Specificity

Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in s

Database Links

HGNC: 1087

OMIM: 605404

KEGG: hsa:666

STRING: 9606.ENSP00000314132

UniGene: Hs.293753

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Code	CSB-PA892353LA01HU
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BOK Antibody

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Target Background