BRD8 Antibody

Datasheet

Code	CSB-PA880933LA01HU
Size	US$166
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Image	Immunohistochemistry analysis of human lung cancer using CSB-PA880933LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BRD8 Polyclonal antibody

Uniprot No.

Q9H0E9

Target Names

BRD8

Alternative Names

BRD8 antibody; SMAP antibody; SMAP2 antibody; Bromodomain-containing protein 8 antibody; Skeletal muscle abundant protein antibody; Skeletal muscle abundant protein 2 antibody; Thyroid hormone receptor coactivating protein of 120 kDa antibody; TrCP120 antibody; p120 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bromodomain-containing protein 8 protein (641-859AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BRD8 Antibody (Product code: CSB-PA880933LA01HU) is Non-conjugated. For BRD8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA880933LB01HU	BRD8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA880933LC01HU	BRD8 Antibody, FITC conjugated
Biotin	CSB-PA880933LD01HU	BRD8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Gene References into Functions

miR-185 can attenuate androgen receptor function indirectly by suppressing BRD8 ISO2 PMID: 26940039
incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation PMID: 23064015
SMAP gene family constitutes an important ArfGAP subfamily, with each SMAP member exerting both common and distinct functions in vesicle trafficking. PMID: 16571680
BRD8 expression is associated with tumor progression toward advanced stages PMID: 19787264

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Database Links

HGNC: 19874

OMIM: 602848

KEGG: hsa:10902

STRING: 9606.ENSP00000254900

UniGene: Hs.519337

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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