BRSK1 Antibody

Datasheet

Code	CSB-PA837438LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse heart tissue, Mouse lung tissue, Mouse kidney tissue All lanes: BRSK1 antibody at 3.5μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 86, 87, 39 kDa Observed band size: 86, 39 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA837438LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA837438LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BRSK1 Polyclonal antibody

Uniprot No.

Q8TDC3

Target Names

BRSK1

Alternative Names

BR serine/threonine kinase 1 antibody; BR serine/threonine protein kinase 1 antibody; BR serine/threonine-protein kinase 1 antibody; Brain selective kinase 1 antibody; Brain-specific serine/threonine-protein kinase 1 antibody; BRSK 1 antibody; Brsk1 antibody; BRSK1_HUMAN antibody; FLJ43009 antibody; hSAD1 antibody; KIAA1811 antibody; Protein kinase SAD1A antibody; SAD 1 antibody; SAD1 antibody; SAD1 homolog antibody; SAD1 kinase antibody; SAD1A antibody; SADB antibody; SadB kinase short isoform antibody; Serine/threonine kinase SAD B antibody; Serine/threonine-protein kinase SAD-B antibody; Synapses of Amphids Defective homolog antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BRSK1 Antibody (Product code: CSB-PA837438LA01HU) is Non-conjugated. For BRSK1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA837438LB01HU	BRSK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA837438LC01HU	BRSK1 Antibody, FITC conjugated
Biotin	CSB-PA837438LD01HU	BRSK1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Gene References into Functions

These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer. PMID: 27677186
BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression. PMID: 25036402
Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan. PMID: 22131368
acts as checkpoint kinase upon DNA damage induced by UV PMID: 15150265
protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2. PMID: 18339622
STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 PMID: 18854318
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. PMID: 19648910

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily

Tissue Specificity

Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.

Database Links

HGNC: 18994

OMIM: 609235

KEGG: hsa:84446

STRING: 9606.ENSP00000310649

UniGene: Hs.182081

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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