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BTBD10 Antibody

Datasheet
Code CSB-PA002841GA01HU
Size $600
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Product Details

Uniprot No.
Q9BSF8
Target Names
BTBD10
Alternative Names
BTBD10 antibody; GMRP1BTB/POZ domain-containing protein 10 antibody; Glucose metabolism-related protein 1 antibody
Species Reactivity
Human,Mouse,Rat
Immunogen
Human BTBD10
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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BTBD10 Proteins

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Target Background

Function
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
Gene References into Functions
  1. findings suggest that reduced BTBD10 expression is closely linked to the pathogenesis of sporadic amyotrophic lateral sclerosis PMID: 23320755
  2. Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo. PMID: 22388351
  3. GMRP1 regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway. PMID: 21267538
  4. BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation. PMID: 18160256
Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma.
Database Links

HGNC: 21445

OMIM: 615933

KEGG: hsa:84280

STRING: 9606.ENSP00000278174

UniGene: Hs.332382

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