C2CD3 Antibody

Datasheet

Code	CSB-PA673367LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA673367LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA673367LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA673367LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) C2CD3 Polyclonal antibody

Uniprot No.

Q4AC94

Target Names

C2CD3

Alternative Names

C2CD3 antibody; C2 domain-containing protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C2 domain-containing protein 3 protein (2079-2265AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The C2CD3 Antibody (Product code: CSB-PA673367LA01HU) is Non-conjugated. For C2CD3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA673367LB01HU	C2CD3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA673367LC01HU	C2CD3 Antibody, FITC conjugated
Biotin	CSB-PA673367LD01HU	C2CD3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.

Gene References into Functions

Our data provide further evidence that mutations in C2CD3 cause a ciliopathy in humans and expand the previously reported phenotype resulting from C2CD3 dysfunction. PMID: 27094867
we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD) syndrome PMID: 25412110
Loss of C2CD3 results in short centrioles without subdistal and distal appendages. PMID: 24997988

Involvement in disease

Orofaciodigital syndrome 14 (OFD14)

Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.

Database Links

HGNC: 24564

OMIM: 615944

KEGG: hsa:26005

STRING: 9606.ENSP00000323339

UniGene: Hs.557938

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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