C9orf89 Antibody

Code CSB-PA788857
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using C9orf89 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CARD19 Polyclonal antibody
Uniprot No.
Target Names
CARD19
Alternative Names
Bcl10 interacting protein with CARD protein antibody; Bcl10-interacting CARD protein antibody; BINCA_HUMAN antibody; BinCARD antibody; C9orf89 antibody; Chromosome 9 open reading frame 89 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human C9orf89.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Gene References into Functions
  1. the crystal structure of BinCARD reveals that all three cysteines were oxidized PMID: 23633586
  2. BinCard inhibits BCL10-mediated activation of NF-kappa B. PMID: 15637807
Subcellular Location
[Isoform 1]: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity
Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.
Database Links

HGNC: 28148

OMIM: 617726

KEGG: hsa:84270

UniGene: Hs.434213

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