CACNA1E Antibody

Code CSB-PA952659
Size US$166
Order now
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA952659(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA952659(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
Alternative Names
alpha-1 polypeptide antibody; BII antibody; Brain calcium channel II antibody; CAC 1E antibody; CAC1E antibody; CAC1E_HUMAN antibody; CACH 6 antibody; CACH6 antibody; CACNA1E antibody; Cacnl1 a6 antibody; CACNL1A6 antibody; Calcium channel antibody; Calcium channel; L type; alpha 1 polypeptide; isoform 6 antibody; calcium channel; R type antibody; Cav 2.3 antibody; Cchra 1 antibody; Cchra1 antibody; isoform 6 antibody; L type antibody; Voltage dependent R type calcium channel subunit alpha 1E antibody; Voltage gated calcium channel subunit alpha Cav2.3 antibody; Voltage-dependent R-type calcium channel subunit alpha-1E antibody; Voltage-gated calcium channel subunit alpha Cav2.3 antibody
Raised in
Species Reactivity
Synthetic peptide of Human CACNA1E
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Gene References into Functions
  1. This study identified a polymorphism in exon 20 of the CACNA1E gene (Asp859Glu - rs35737760) that is more prevalent in hemiplegic and brain stem aura migraine. PMID: 28573794
  2. Carriers of the minor G allele of the rs3845446 SNP exhibited enhanced pain-related phenotypes after gastrointestinal surgery. The pain-related phenotypes of carriers of the minor allele of this SNP after gastrointestinal surgery were opposite to such phenotypes after orthognathic surgery. PMID: 27480382
  3. Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1) induces sustained increase in nuclear Ca2+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane. PMID: 25741585
  4. CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity. PMID: 23940630
  5. The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines PMID: 22633975
  6. quartet of leucine residues in the guanylate kinase domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel. PMID: 22846999
  7. CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes. PMID: 22427875
  8. the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 and that this binding promotes internalization of the channel PMID: 22178872
  9. Ca(v)2.3 Ca2+ channel interacts with the G1-subunit of V-ATPase. PMID: 21691059
  10. Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy. PMID: 21482359
  11. Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes. PMID: 20026913
  12. Review discusses the roles of Cav2.3-containing E-type Ca2+ channels which exhibit several subunit-specific features, trigger exocytosis and are also involved in long-term potentiation. PMID: 15845089
  13. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. PMID: 16855219
  14. Neurokinin 1 receptorsmodulate CaV2.3 using three different signaling mechanisms: a fast inhibition mediated by Gbeta gamma, a slow inhibition mediated by Galpha(q/11), and a slow stimulation mediated by protein kinases C. PMID: 17050807
  15. Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. PMID: 17189400
  16. analysis of a three-dimensional homology model of Ca(V)2.3 based upon Kv1.2 where hydrophobic residues at positions facing Val(1720) in IS6, IIS6, and IIIS6 play a critical role in stabilizing the closed state in Ca(V)2.3 PMID: 17660294
  17. A functional variant in CACNA1E contributes to type 2 diabetes susceptibility in Pima indians by affecting insulin action. PMID: 17720895
  18. Genetic variation in the CACNA1E gene contributes to an increased risk of the development of type 2 diabetes by reducing insulin secretion. PMID: 17934712
  19. These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3. PMID: 18037383

Show More

Hide All

Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1E subfamily
Tissue Specificity
Expressed in neuronal tissues and in kidney.
Database Links

HGNC: 1392

OMIM: 601013

KEGG: hsa:777

STRING: 9606.ENSP00000356545

UniGene: Hs.437444

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details


II. Contact details


III. Ship To


IV. Bill To