CACNA1G Antibody

1. T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to alphaCaMKII activation. PMID: 28800734
2. Cacna1g exclusively expressed in serosal PDGFRalpha+ cells is a new pathological marker for gastrointestinal diseases. PMID: 28806761
3. Electrophysiological studies showed a significant increase in Cd(2+) and manganese (Mn(2+)) currents through the CaV3.1 mutants as well as a reduction in the inhibitory effect of Cd(2+) on the Ca(2+) current. PMID: 27134080
4. The results of this study provide support for Cacna1g as a genetic modifier in a mouse model of Dravet syndrome and suggest that Cav3.1 may be a potential molecular target for therapeutic intervention in patients PMID: 28556246
5. CACNA1G variant is associated with differential antiepileptic drug response in childhood absence epilepsy. PMID: 28165634
6. In 2 families with autosomal dominant SCA, a CACNA1G mutation p.Arg1715His was found at S4 of repeat IV, the voltage sensor of the CaV3.1 which shifted it toward a positive potential. PMID: 26715324
7. A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia. PMID: 26456284
8. CaV3.1 channel is required for the generation of a given set of thalamocortical rhythms during unconsciousness. Further, that thalamocortical resonant neuronal activity supported by this channel is important for the control of vigilance states PMID: 26056284
9. CaV3.1 downregulation is a major initiating factor for the increased production of the toxic Ab peptide, then the CaV3.1 T-type calcium channel represents a novel target for preventative therapeutics in Alzheimer's disease. PMID: 24268883
10. Ethanol affects CaV3.2 but not CaV3.1 nor CaV3.3 channel isoforms. PMID: 23488970
11. Cd(2) carried sizable inward currents through Ca(v)3.1 channels (210 +/- 20 pA at -60 mV with 2 mM Cd(2)). PMID: 22973059
12. Ca(V)3.1 channels represent a likely pathway for Fe(2) entry into cells. PMID: 22973060
13. Augmentation of CaV3.1 currents by Ras-ERK activation is associated with enhanced trafficking of channels to the plasma membrane. PMID: 22572848
14. Cav3.1 channels may contribute to the repression of tumor proliferation and the promotion of apoptosis mediated via Cav3.1-specific calcium signals PMID: 22469755
15. establishing CACNA1G as a novel candidate gene for autism, these alleles do not contribute a sufficient genetic effect to explain the observed linkage, indicating that there is substantial genetic heterogeneity despite the clear linkage signal PMID: 19455149
16. Results reveal an intracellular WPb-independent P-selectin pool in pulmonary capillary endothelium, where the regulated P-selectin surface expression is triggered by Ca(2+) transients evoked through activation of the alpha(1G) T-type channel. PMID: 20435690
17. Since allele and genotype distributions of CACNA1G polymorphisms in cases studied are not remarkably different from control groups, CACNA1G is not an important susceptibility gene for childhood absence epilepsy in the Han Chinese population. PMID: 12676336
18. The down-regulation of alpha 1G T-type calcium channel mRNA in differentiated Y79 cells is mediated primarily by decreased activity of promoter A, which could occur in conjunction with repression of the activity of promoter B. PMID: 12752779
19. Data describe the construction of a new cell line stably expressing alpha(1G) and Kir2.1 subunits in HEK293 cells. PMID: 15465033
20. T-type voltage-operated Ca2+ channels are required for cell cycle progression and proliferation of human pulmonary artery smooth muscle cell. PMID: 15774856
21. CACNA1G is a human gene for T-type Ca(v)3.1 calcium channels that is subject to extensive alternative RNA splicing PMID: 16671074
22. collective findings flag CACNA1G as a potential susceptibility locus for idiopathic generalized epilepsy subsyndromes PMID: 17397049
23. Primary T-type subunit expressed in some myometrial smooth muscle cells is Cav3.1. PMID: 17446221
24. A panel of markers including at least RUNX3, CACNA1G, IGF2, and MLH1 can serve as a sensitive and specific marker panel for CIMP(Cpg island methylator phenotype)-high. PMID: 17591929
25. This study reports the concentration dependence of currents through Ca(V)3.1 T-type calcium channels stably expressed in HEK 293 cells. PMID: 18663131
26. A study evaluating whether the effect of Ni(2+) on Ca(V)3.1 is affected by permeant ions is reported. PMID: 18663132
27. These results suggest that RanBPM could be a key regulator of Ca(v)3.1 channel-mediated signaling pathways. PMID: 18801335
28. Elevated brain levels of Cacna1g channel identify a key causal component of pure absence epilepsy and a major genetic component of the epileptogenic pathway. PMID: 19211869

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HGNC: 1394

OMIM: 604065

KEGG: hsa:8913

STRING: 9606.ENSP00000352011

UniGene: Hs.591169