CAPRIN2 Antibody, FITC conjugated

Code CSB-PA740238OC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CAPRIN2 Polyclonal antibody
Uniprot No.
Target Names
CAPRIN2
Alternative Names
C1q domain-containing protein 1 antibody; C1QDC1 antibody; CAPR2_HUMAN antibody; Caprin family member 2 antibody; Caprin-2 antibody; caprin2 antibody; Cytoplasmic activation/proliferation-associated protein 2 antibody; EEG 1 antibody; EEG1 antibody; Gastric cancer multidrug resistance-associated protein antibody; KIAA1873 antibody; Protein EEG-1 antibody; RNA granule protein 140 antibody; RNG140 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Caprin-2 protein (83-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Gene References into Functions
  1. findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6. PMID: 27821587
  2. Caprin-2 C1q-related domain forms a flexible homotrimer mediated by calcium, and this trimeric assembly is required for the functioning of caprin-2. PMID: 25331957
  3. regulated expression of EEG-1 is involved in the orchestrated regulation of growth that occurs as erythroblasts shift from a highly proliferative state toward their terminal phase of differentiation. PMID: 14593112
  4. Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation. PMID: 18762581
Subcellular Location
[Isoform 1]: Cytoplasm.; [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.; [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.; Cell membrane; Peripheral membrane protein.
Protein Families
Caprin family
Tissue Specificity
Detected in all tissues tested with highest levels of expression in brain and spleen.
Database Links

HGNC: 21259

OMIM: 610375

KEGG: hsa:65981

UniGene: Hs.234355

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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